Polyarticular juvenile idiopathic arthritis

This trial tests whether a brief vocational rehabilitation program can help people with arthritis who are worried about losing their jobs. Participants, all currently employed and living or working in eastern Massachusetts, will work with a physical or occupational therapist to i…

This study looked at the long-term safety and effectiveness of the Birmingham Hip Resurfacing System, a metal hip implant, in 329 adults with arthritis. The main goal was to see how many patients needed a revision (replacement or removal) within 10 years. The study also measured …

This study looked at 62 children with juvenile idiopathic arthritis whose disease was inactive. Researchers tested whether slowly reducing and then stopping their biologic medication was as safe and effective as staying on the full dose for 24 weeks. The goal was to see if taperi…

This study tested whether adding leflunomide to standard methotrexate treatment helps children with polyarticular juvenile idiopathic arthritis (JIA) that did not improve with methotrexate alone. Fifty children were randomly assigned to receive either the combination or methotrex…

This study looked at how well a specific knee replacement (balanSys UNI) works over time. 116 people with knee arthritis got the implant and were followed for at least 2 years. Doctors measured knee function using the Knee Society Score and checked X-rays for any problems.

This study tested whether a weekly injection of abatacept (Orencia) plus usual care could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. 121 children with recent-onset JIA affecting 4 or fewer joints took part. The goal was …

This study tested an intravenous drug called golimumab in 130 children with active juvenile idiopathic arthritis that did not improve with methotrexate. The main goal was to measure how the drug moves through the body over time. The study was completed and provides information on…

This study looked at the long-term safety of the drug tocilizumab (Actemra) in 7 children with a type of arthritis called juvenile idiopathic arthritis. All children had already completed a previous study and continued to receive the drug every 4 weeks for up to 2 years. The main…

This pilot study looked at whether passive static stretching can increase hip flexibility in three groups: people who had hip replacement, those with long-term hip pain, and healthy volunteers. Twelve participants followed a 4-week stretching program three times a week under supe…

This study compared robotic-assisted total knee replacement to the conventional technique in 95 patients with knee arthritis. The goal was to see if robotic surgery leads to better knee function, less pain, and higher satisfaction two years after the operation. Researchers also c…

This study looked at DNA methylation patterns in stored samples from 90 patients with rare skeletal disorders, sarcomas, or inflammatory arthritis. The goal was to better understand these patterns and explore their potential for diagnosis and treatment. The research aimed to impr…

This completed pilot study tested whether training doctors to ask personalized questions (individuation) could improve care for Black and lower-income patients with rheumatic diseases like lupus and arthritis. Over 200 patients and their rheumatologists took part. The goal was to…

This study looked at two different designs of knee replacement implants in 60 people with arthritis. The goal was to see how much each implant moved inside the bone over two years using a special X-ray technique called RSA. The findings could help surgeons pick the better implant…