Peritoneal carcinomatosis

This trial tests whether adding radical surgery to remove the stomach tumor and nearby lymph nodes improves survival and quality of life compared with continuing drug therapy alone in patients with stomach cancer that has spread to the abdominal lining (peritoneal metastasis) and…

This phase II trial is testing whether a combination of low-dose radiation, an immunotherapy drug (serplulimab), and chemotherapy can help people with stomach cancer that has spread to the lining of the abdomen (peritoneal metastasis). The study enrolls adults with HER2-negative …

This phase 2 trial is testing a new, intensive treatment plan for 28 people with advanced ovarian cancer. The approach combines chemotherapy given into the abdomen and vein, a special vaccine made from the patient's own immune cells, and the immunotherapy drug Keytruda. The goal …

This study tests a precise radiation therapy guided by MRI for people with up to 5 spots of cancer spread in the abdomen from stomach, bowel, or ovarian cancers. About 34 adults will receive this non-invasive treatment to shrink tumors and delay the need for chemotherapy. The goa…

This early-stage study tests a new treatment plan for people with stomach or colorectal cancer that has spread to the lining of the abdomen. The approach combines low-dose radiation to the whole abdomen with chemotherapy and an immunotherapy drug. The main goal is to check if the…

This early-phase study tests a new drug combination (PX plus nab-paclitaxel) given directly into the abdomen for people with a type of advanced cancer that has spread to the lining of the belly. The main goal is to find a safe dose and check for side effects. About 22 adults with…

This phase II trial is testing whether adding lubiprostone, a drug usually used for constipation, to standard maintenance therapy can delay cancer recurrence in adults with colorectal cancer that has spread to the lining of the abdomen. About 124 participants who have had surgery…

This study tests a method called PIPAC, where the chemotherapy drug paclitaxel is turned into a pressurized spray and delivered directly into the abdomen. It is for women with ovarian cancer that has come back and no longer responds to platinum-based chemotherapy. The trial has t…

This Phase 2 trial tests whether adding pirfenidone and sintilimab to standard chemotherapy can shrink tumors in 30 people with colorectal cancer that has spread to the lining of the abdomen. Participants will receive the drug combination before any other treatment. The study wil…

This study compares two types of prehabilitation (exercise, nutrition, and psychological support) for 225 women with advanced ovarian cancer. One group starts prehab early during chemotherapy, while the other starts just before surgery. The goal is to see if early prehab reduces …

This pilot study tests whether drinking an omega-3-enriched nutritional supplement for 21 days before surgery can reduce complications in people with abdominal cancer. 28 patients will be randomly assigned to get either the omega-3 drink or a standard supplement. Researchers will…

This study tests whether chewing ginger-mint or cinnamon gum can reduce nausea and vomiting after a specific chemotherapy procedure (PIPAC) for colorectal cancer that has spread to the abdomen. 75 adults will be randomly assigned to chew one of the two flavored gums or receive st…

This study looks at how colorectal cancer grows when it spreads to the lining of the abdomen. Researchers want to see if the pattern of tumor growth can help doctors decide who will benefit most from surgery. The study will follow 30 adults who are already scheduled for surgery o…

This study checks if surgeons can tell key details about ovarian cancer by looking at images from a camera inside the belly. About 70-80 surgeons will review pictures from 19 patients and guess the cancer type and growth pattern. The goal is to see if visual clues can help plan t…

This study tests whether removing a larger piece of the pelvic lining during surgery can find tiny cancer deposits that standard biopsies might miss. About 390 adults with early-stage ovarian or fallopian tube cancer will undergo this procedure. The goal is to improve staging acc…