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Chewing gum may soothe chemo nausea: new study tests ginger and cinnamon

NCT ID NCT07315412

Symptom relief Sponsor: Fenerbahce University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether chewing ginger-mint or cinnamon gum can reduce nausea and vomiting after a specific chemotherapy procedure (PIPAC) for colorectal cancer that has spread to the abdomen. 75 adults will be randomly assigned to chew one of the two flavored gums or receive standard care only. The goal is to find a simple, drug-free way to improve comfort and recovery after treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older undergoing Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). * Able to communicate, understand study instructions, and provide written informed consent. * No known allergy or intolerance to ginger, mint, or cinnamon. * Able and willing to chew gum for 15 minutes. * Apfel risk score ≥3 for postoperative nausea and vomiting. Exclusion Criteria: * Postoperative complications requiring intensive care or reoperation. * Need for rescue antiemetic medication within the first 2 postoperative hours. * History of psychiatric disorder, neurological disease, or cognitive impairment affecting participation. * Anatomical or functional limitation preventing chewing (e.g., full dentures, jaw restriction, oral surgery). * Known phenylketonuria or metabolic intolerance to chewing gum ingredients. * Active chemotherapy, radiotherapy, or immunosuppressive therapy affecting gastrointestinal function.

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Conditions

The condition(s) this trial relates to.

peritoneal carcinomatosis Postoperative Nausea and Vomiting Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intraperitoneal chemotherapy Peritoneal metastases from colorectal cancer Postoperative nausea and vomiting (PONV)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Health Sciences, Umraniye Training and Research Hospital

    Istanbul, 34758, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.