Periodontitis, aggressive 1
MONDO:0008226A localized aggressive periodontitis, formerly called localized juvenile periodontitis. It is a destructive form of periodontitis characterized by ALVEOLAR BONE LOSS of the MOLARS and INCISORS. Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.
Also known as: periodontitis 1, juvenile, periodontitis, aggressive, type 1, periodontitis, aggressive, 1, periodontitis, juvenile, periodontitis, prepubertal
28 clinical trials for this condition and its sub-types, 6 tagged with Periodontitis, aggressive 1 itself.
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New hope for painful hand and foot pustules: phase 3 trial launches
Disease control Recruiting nowThis phase 3 trial tests whether the drug bimekizumab can clear or nearly clear the pustules and skin lesions of palmoplantar pustulosis (PPP) on the hands and feet. About 320 adults with moderate to severe PPP will receive either bimekizumab or a placebo for 16 weeks, with an op…
Phase 3 • Sponsor: UCB Biopharma SRL • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Gum disease treatment: can a hyaluronic acid gel regrow bone as well as the standard?
Disease control Recruiting nowThis study tests whether a hyaluronic acid gel can help regrow bone lost to severe gum disease, compared to the standard enamel matrix derivative gel or no gel at all. All treatments use a minimally invasive, non-surgical technique. Sixty adults with advanced periodontitis will b…
Sponsor: University of Valencia • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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Scientists probe gum tissue to unlock secrets of aggressive periodontitis
Knowledge-focused Recruiting nowThis observational study looks at gum tissue from people with aggressive or chronic periodontitis and healthy gums. Researchers use advanced genetic tools to map cell types and signals that make aggressive disease different. Only small tissue and blood samples are taken during pl…
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Gum disease breakthrough? scientists investigate immune cells for better diagnosis
Knowledge-focused Recruiting nowThis study examines how B cells, a type of immune cell, behave in the blood and gums of people with periodontitis (gum disease). Researchers want to see if certain B cell patterns are linked to more aggressive disease and how they change after surgery. The goal is to improve diag…
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:02 UTC