Patent ductus arteriosus
MONDO:0011827A congenital defect characterized by the failure of the ductus arteriosus to close soon after birth. As a consequence, blood from the aorta mixes with blood from the pulmonary artery. If untreated, it may lead to congestive heart failure.
Also known as: PDA, patent ductus arteriosus, patent ductus botalli, persistent patency of the arterial duct, patency of the ductus arteriosus, patent ductus arteriosus familial (type)
102 clinical trials for this condition and its sub-types, 28 tagged with Patent ductus arteriosus itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Patent ductus arteriosus
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Char syndrome 0 trials
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PDA1 0 trials
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Patent ductus arteriosus 2 0 trials
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Patent ductus arteriosus 3 0 trials
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Tiny heart, tiny device: new hope for premature babies
Disease control OngoingThis study tests a small device called the BLOOM Micro-Occluder to close a common heart hole (PDA) in premature babies. About 55 babies weighing between 600 and 2500 grams will be enrolled. The goal is to see if the device is safe and works well over 6 months.
Sponsor: Merit Medical Systems, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New study weighs risks of treating vs. watching heart defect in preemies
Disease control OngoingThis study looks at whether actively treating a heart condition called patent ductus arteriosus (PDA) in premature babies is better than simply monitoring it. About 482 infants born between 22 and 28 weeks of pregnancy will be followed to see which approach reduces the risk of de…
Phase 3 • Sponsor: NICHD Neonatal Research Network • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Could a steroid shot help tiny preemies survive shock?
Disease control OngoingThis study tests whether giving the steroid hydrocortisone early, right when shock is diagnosed, helps very small preterm babies (under 1500 grams) recover faster. Researchers will compare babies who get standard shock treatment plus hydrocortisone to those who get standard treat…
Phase 4 • Sponsor: Coordinación de Investigación en Salud, Mexico • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Heart device for preemies under scrutiny in new safety study
Disease control OngoingThis study monitors 70 infants who receive the Amplatzer Piccolo Occluder to close a hole in the heart called patent ductus arteriosus (PDA). The device is placed through a blood vessel, avoiding open-heart surgery. Researchers track complications and how well the hole closes ove…
Sponsor: Abbott Medical Devices • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Tiny hearts, tiny kidneys: new study monitors oxygen in preterm infants
Knowledge-focused OngoingThis study looks at oxygen levels in the kidneys of premature babies born before 32 weeks who have a heart condition called patent ductus arteriosus (PDA). Researchers want to see how kidney oxygen relates to the severity of the heart condition and whether it can predict kidney i…
Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Sep 21, 2026 16:00 UTC
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Study aims to predict which preterm babies need treatment for a heart vessel that often closes on its own
Knowledge-focused OngoingThis study follows 526 preterm infants born before 30 weeks who have a condition called patent ductus arteriosus (PDA), where a fetal blood vessel stays open too long. Researchers collect heart ultrasound, blood, and urine tests over the first month to predict which babies will c…
Sponsor: Nationwide Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC