Parkinsonian disorder
MONDO:0021095A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
1315 clinical trials for this condition and its sub-types, 67 tagged with Parkinsonian disorder itself.
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Sub-types of Parkinsonian disorder
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Parkinson disease 1,169 trials · 1,296 incl. sub-types
6 sub-types
- Late-onset Parkinson disease 3 trials · 143 incl. sub-types Sub-types →
- Young-onset Parkinson disease 9 trials · 11 incl. sub-types Sub-types →
- Parkinson disease 16 0 trials
- Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development 0 trials
- Parkinson disease, mitochondrial 0 trials
- Parkinsonian-pyramidal syndrome 0 trials Sub-types →
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Vascular parkinsonism 4 trials
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Dystonia 12 2 trials
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Perry syndrome 0 trials
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X-linked dystonia-parkinsonism 0 trials
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Atypical juvenile parkinsonism 0 trials
1 sub-type
- Juvenile onset Parkinson disease 19A 0 trials
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Cyanide-induced parkinsonism 0 trials
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Dystonia 16 0 trials
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Encephalitis lethargica 0 trials
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Parkinsonism with polyneuropathy 0 trials
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Parkinsonism-dystonia, infantile 0 trials
3 sub-types
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Postencephalitic Parkinson disease 0 trials
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Primary progressive freezing gait 0 trials
Most studied deeper sub-types
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A nurse coordinator might be the key to better Parkinson's care
Disease control CompletedThis trial tests whether having a nurse specialist coordinate care for people with Parkinson's or related conditions improves their quality of life over 12 months. Participants are randomly assigned to either standard care with their neurologist or additional support from a nurse…
Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Planning ahead: could a simple program transform Parkinson's care?
Disease control CompletedThis trial tests a program called PD_Pal, where a specially trained nurse helps people with Parkinson's and their family caregivers create a personalized care plan. The plan covers current care, future needs, and end-of-life preferences, aiming to ensure that care matches what th…
Sponsor: Radboud University Medical Center • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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New Parkinson's drug shows promise in Year-Long trial
Disease control CompletedThis study tested the safety and effectiveness of tavapadon, an experimental drug, in 992 people with Parkinson's disease over 58 weeks. Participants took flexible doses of the medication to see how well it controlled symptoms and what side effects occurred. The goal was to under…
Phase 3 • Sponsor: AbbVie • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New drug tavapadon tested to ease Parkinson's symptoms
Disease control CompletedThis Phase 3 trial tested whether tavapadon, a daily pill, can improve movement and daily activities in people with early Parkinson's disease. Over 300 participants took either tavapadon or a placebo for 27 weeks. The study measured changes in motor function and daily living skil…
Phase 3 • Sponsor: AbbVie • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Smart sensors could spot Parkinson's earlier and more accurately
Diagnosis CompletedThis study aims to develop computer models that can help diagnose and monitor Parkinson's disease by analyzing eye movements and walking patterns. Researchers will collect data from 100 people with Parkinson's or similar conditions using special devices. The goal is to make diagn…
Sponsor: machineMD AG • Aim: Diagnosis
Last updated Sep 11, 2026 00:00 UTC
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Brain-Scan AI could spot Parkinson's without costly PET imaging
Diagnosis CompletedThis completed trial tested a software called mPDia that uses MRI brain scans to help doctors diagnose neurodegenerative parkinsonism, a group of movement disorders including Parkinson's disease. The study involved 221 adults and compared mPDia's accuracy to standard PET scans. T…
Sponsor: Heuron Inc. • Aim: Diagnosis
Last updated Jun 27, 2026 07:55 UTC
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Can a One-Time bone drug shield Parkinson's patients from fractures?
Prevention CompletedThis study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…
Phase 4 • Sponsor: California Pacific Medical Center Research Institute • Aim: Prevention
Last updated Jun 27, 2026 14:01 UTC
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Bubble therapy shows promise for Parkinson's symptoms
Symptom relief CompletedThis study tested whether infusing tiny bubbles of oxyhydrogen gas could help people with Parkinsonism. 35 adults received the infusion alongside their usual care. Researchers measured changes in disease severity, thinking ability, and quality of life. The goal was to see if this…
Phase 2/3 • Sponsor: dr. Siti Nurlaela, SpN • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Talking to a speaker may boost mood in Parkinson's
Symptom relief CompletedThis pilot study tested whether using a voice-activated smart speaker (Apple HomePod mini) could improve psychosocial well-being in 48 people with Parkinson's disease. Participants in the intervention group received a user protocol, the device, training, and tech support for 8 we…
Sponsor: The Hong Kong Polytechnic University • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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New Parkinson's care model puts patients in the Driver's seat
Symptom relief CompletedThis study tested a new way of caring for people with Parkinson's disease. The goal was to help 214 participants achieve their personal goals and improve their quality of life. The approach involved proactive, integrated care and patient empowerment, compared to standard care.
Sponsor: University of Bristol • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Scientists dig into DNA to unlock secrets of early Parkinson's
Knowledge-focused CompletedThis completed study looked at 31 people with early-onset Parkinson's disease (starting before age 50) and their family members to find genetic causes. Researchers collected blood and skin samples to study DNA and create cell lines. The goal was to better understand which gene mu…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
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New brain scans aim to unlock Parkinson's mysteries
Knowledge-focused CompletedThis study used brain imaging to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to six visits over nine years, including MRI scans and symptom checks. The…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
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Scientists watch tremors up close to unlock brain secrets
Knowledge-focused CompletedThis study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
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AI vs. experts: can machines master Parkinson's motor scoring?
Knowledge-focused CompletedThis trial tests whether a machine vision system can accurately rate the motor symptoms of Parkinson's disease, as measured by the MDS-UPDRS Part III scale. Researchers will record videos of patients performing standardized tasks and use machine learning to develop an AI rating m…
Sponsor: Ruijin Hospital • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC
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Gene mutation may amplify cognitive risks of brain stimulation in Parkinson's
Knowledge-focused CompletedThis study investigates whether Parkinson's disease patients who carry a mutation in the GBA gene are more likely to experience cognitive decline after deep brain stimulation (DBS) surgery. Researchers will compare thinking and memory test results in 150 patients with and without…
Sponsor: Rutgers, The State University of New Jersey • Aim: Knowledge-focused
Last updated Jul 31, 2026 00:00 UTC
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Parkinson's Patients' hospital stays under the microscope
Knowledge-focused CompletedThis completed study looked at over 2,500 people with Parkinson's disease who were admitted to the hospital through the emergency room. Researchers wanted to find the main reasons for these hospital stays and compare them to people of the same age without Parkinson's. The goal wa…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Watching mealtimes: new study reveals hidden strategies for Parkinson's swallowing difficulties
Knowledge-focused CompletedThis study looked at how people with Parkinson's disease who have trouble swallowing and their caregivers work together during meals. Researchers filmed 22 patient-caregiver pairs and interviewed them to understand the verbal and non-verbal strategies used to make eating safer an…
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Parkinson's drug study aims to uncover disease clues
Knowledge-focused CompletedThis early-phase study tested the safety of a drug called sargramostim (Leukine) in 11 people with Parkinson's disease over 48 weeks. Researchers also looked for changes in immune cells and other biomarkers that might help track the disease. The goal was not to cure Parkinson's b…
Phase 1 • Sponsor: University of Nebraska • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Your walk could diagnose brain disease
Knowledge-focused CompletedThis study from the University of Zurich looked at how people with different neurological conditions walk. Researchers measured walking patterns in 208 adults, including those with stroke, Parkinson's, multiple sclerosis, and spinal cord injury, as well as healthy volunteers. The…
Sponsor: University of Zurich • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC