Paraplegia
MONDO:0003757Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord.
Also known as: severe or complete loss of motor function in the lower extremities and lower portions of the trunk
68 clinical trials for this condition and its sub-types, 47 tagged with Paraplegia itself.
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Sub-types of Paraplegia
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Hereditary spastic paraplegia 27 trials · 33 incl. sub-types
45 sub-types
- Complex hereditary spastic paraplegia 1 trial · 7 incl. sub-types Sub-types →
- Hereditary spastic paraplegia 50 3 trials
- Hereditary spastic paraplegia 3A 2 trials
- Hereditary spastic paraplegia 4 2 trials
- Hereditary spastic paraplegia 5A 2 trials
- Hereditary spastic paraplegia 47 1 trial
- Hereditary spastic paraplegia 51 1 trial
- Hereditary spastic paraplegia 52 1 trial
- Hereditary spastic paraplegia 7 1 trial
- ADAR-related hereditary spastic paraplegia 0 trials
- Charcot-Marie-Tooth disease type 5 0 trials
- IFIH1-related hereditary spastic paraplegia 0 trials
- RNASEH2B-related hereditary spastic paraplegia 0 trials
- Early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome 0 trials
- Hereditary spastic paraplegia 10 0 trials
- Hereditary spastic paraplegia 13 0 trials
- Hereditary spastic paraplegia 14 0 trials
- Hereditary spastic paraplegia 16 0 trials
- Hereditary spastic paraplegia 2 0 trials
- Hereditary spastic paraplegia 30 0 trials Sub-types →
- Hereditary spastic paraplegia 31 0 trials
- Hereditary spastic paraplegia 33 0 trials
- Hereditary spastic paraplegia 35 0 trials
- Hereditary spastic paraplegia 48 0 trials
- Hereditary spastic paraplegia 56 0 trials
- Hereditary spastic paraplegia 6 0 trials
- Hereditary spastic paraplegia 77 0 trials
- Macrocephaly-spastic paraplegia-dysmorphism syndrome 0 trials
- Mast syndrome 0 trials
- Pure hereditary spastic paraplegia 0 trials Sub-types →
- Pure or complex hereditary spastic paraplegia 0 trials
- Spastic paraplegia 72b, autosomal recessive 0 trials
- Spastic paraplegia 79A, autosomal dominant, with ataxia 0 trials
- Spastic paraplegia 80, autosomal dominant 0 trials
- Spastic paraplegia 81, autosomal recessive 0 trials
- Spastic paraplegia 82, autosomal recessive 0 trials
- Spastic paraplegia 83, autosomal recessive 0 trials
- Spastic paraplegia 87, autosomal recessive 0 trials
- Spastic paraplegia 88, autosomal dominant 0 trials
- Spastic paraplegia 89, autosomal recessive 0 trials
- Spastic paraplegia 90A, autosomal dominant 0 trials
- Spastic paraplegia 90B, autosomal recessive 0 trials
- Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia 0 trials
- Spastic paraplegia 92, autosomal recessive 0 trials
- Spastic paraplegia 93, autosomal recessive 0 trials
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Brown-Sequard syndrome 0 trials
Most studied deeper sub-types
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Can ultrasound make botox injections more precise for stiff muscles?
Disease control Recruiting nowThis trial tests whether using ultrasound to guide botulinum toxin injections into spastic leg muscles works better than the standard method of relying on touch and anatomical landmarks. Researchers will give 40 adults with spastic paraplegia two rounds of injections, one with ea…
Phase 4 • Sponsor: Universidade Federal Fluminense • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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Wearable robot aims to rewire the brain after severe stroke
Disease control Recruiting nowThis study tests a wearable rehabilitation robot designed for stroke survivors with severe leg paralysis. The robot guides patients through motor relearning and passive stretching exercises while they are still in bed during the early acute phase after a stroke. The goal is to se…
Phase 1/2 • Sponsor: University of Maryland, Baltimore • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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Implanted electrical system aims to restore movement in paralyzed limbs
Disease control Recruiting nowThis study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants …
Sponsor: Case Western Reserve University • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Gene therapy aims to halt rare childhood paralysis disorder
Disease control Recruiting nowThis trial tests a single injection of MELPIDA, a gene therapy that delivers a working copy of the AP4M1 gene directly into the spinal fluid of children with SPG50. SPG50 is a rare genetic condition that causes muscle stiffness, intellectual disability, and developmental delays. …
Phase 1/2 • Sponsor: Elpida Therapeutics SPC • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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Could an Alzheimer's drug help treat metabolic syndrome in spinal cord injury?
Disease control Recruiting nowThis pilot study is testing whether galantamine, a drug already approved for Alzheimer's disease, can safely reduce inflammation and treat metabolic syndrome in people with chronic spinal cord injury. The study will enroll 60 adults who use wheelchairs and have obesity-related wa…
Phase 2/3 • Sponsor: Northwell Health • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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Brain zaps could help paralyzed patients walk again
Disease control Recruiting nowThis early-stage trial tests whether deep brain stimulation (DBS) of a brain region called the mesencephalic locomotor region can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS implant and be followed for safety and walking abil…
Sponsor: University of Zurich • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Hope for kids with rare paralysis: gene therapy trial launches
Disease control Recruiting nowThis phase 3 trial tests a one-time gene therapy called MELPIDA for children with SPG50, a rare genetic disease that causes progressive paralysis and developmental delays. The study will give the treatment via a spinal injection to 24 children aged 4 months to 6 years and compare…
Phase 3 • Sponsor: Elpida Therapeutics SPC • Aim: Disease control
Last updated Jun 27, 2026 12:10 UTC
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Spinal implant sparks hope for leg movement in paralyzed patients
Disease control Recruiting nowThis study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with complete spinal cord injuries between C6 and T10. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. Participants must be at least 22,…
Sponsor: University of Minnesota • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Robotic suit aims to get spinal injury patients back on their feet
Disease control Recruiting nowThis study is testing a robotic exoskeleton called TWIICE Rise to see if it is safe and practical for people with spinal cord injury to use for walking. The trial involves 15 participants and will take place in clinics, homes, and community settings. The goal is to assess how wel…
Sponsor: TWIICE • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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New Hands-Free exoskeleton aims to restore mobility in spinal cord injury patients
Disease control Recruiting nowThis study is testing a personal exoskeleton that lets people with spinal cord injury walk hands-free and stay balanced on their own. Twelve participants with injuries at or above the T6 level will train with the device over several sessions. The goal is to see if the exoskeleton…
Sponsor: Wandercraft • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Hands-free robot suit lets people with spinal cord injury walk and do daily tasks
Disease control Recruiting nowThis study tests a hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk and perform everyday activities. The trial will enroll 24 participants who will train with the device over several sessions. Researchers will measure how quickly they ca…
Sponsor: Wandercraft • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Shocking bladder trouble away: nerve zap trial for spinal injury patients
Disease control Recruiting nowThis study tests whether a daily 30-minute nerve stimulation (TTNS) can prevent bladder overactivity that can damage kidneys after spinal cord injury. 114 patients with acute spinal injury will receive either real or sham stimulation for 6-9 weeks. The goal is to see if the treat…
Sponsor: University of Zurich • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Spinal cord injury patients may regain seated control with implanted device
Disease control Recruiting nowThis study is testing a surgically implanted device that uses small electrical currents to stimulate nerves and muscles in the trunk and hips. The goal is to help people with spinal cord injury improve their seated posture, balance, breathing, reaching, and ability to push a whee…
Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Magic mushrooms tested for depression in veterans with spinal injuries
Symptom relief Recruiting nowThis study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…
Phase 1/2 • Sponsor: James J. Peters Veterans Affairs Medical Center • Aim: Symptom relief
Last updated Aug 12, 2026 00:00 UTC
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Could a TENS device stop bowel accidents in spinal injury?
Symptom relief Recruiting nowThis study tests whether using a small electrical stimulation device on the skin near the genitals can help people with spinal cord injury control bowel accidents. Twelve participants will use the device at home for 6-8 hours daily over 4 weeks. The goal is to see if this approac…
Sponsor: MetroHealth Medical Center • Aim: Symptom relief
Last updated Jul 30, 2026 00:00 UTC
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Robot rehab: new device aims to jumpstart recovery after traumatic brain injury
Symptom relief Recruiting nowThis study tests a wearable ankle robot designed for early rehabilitation in patients with traumatic brain injury. The robot guides motor relearning and provides passive or active movement training, even for paralyzed patients. Researchers will measure improvements in ankle movem…
Sponsor: University of Maryland, Baltimore • Aim: Symptom relief
Last updated Jul 19, 2026 00:00 UTC
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Exoskeleton breakthrough: walk Hands-Free after spinal injury?
Symptom relief Recruiting nowThis study tests a new hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk again. Ten adults with paralysis or weakness in their legs will train with the device over several sessions. The goal is to see if the exoskeleton is safe and helps …
Sponsor: Wandercraft • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Robotic suit lets paralyzed individuals walk hands-free – trial underway
Symptom relief Recruiting nowThis study is testing a personal exoskeleton that helps people with spinal cord injury stand, walk, and move without using their hands. The device is self-balancing, so users don't need crutches or a walker. Researchers will see if 24 participants can complete walking tests and e…
Sponsor: Wandercraft • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Could a TENS unit stop bowel accidents after spinal injury?
Symptom relief Recruiting nowThis study tests whether gentle electrical stimulation of a nerve in the genital area can improve bowel control in people with spinal cord injury. Researchers will measure how the rectum and anus respond to the stimulation using a small balloon. The goal is to see if this non-inv…
Sponsor: MetroHealth Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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Remote coaching boosts wheelchair skills in new study
Knowledge-focused Recruiting nowThis study tests whether a remote training program can help manual wheelchair users improve their skills. Researchers will train peer coaches, then enroll 132 wheelchair users to receive either remote feedback training or be placed on a waitlist. The goal is to see if remote trai…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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Scientists launch major effort to track rare nerve disease in children
Knowledge-focused Recruiting nowThis study collects health information and biological samples from up to 700 people under 30 with early-onset hereditary spastic paraplegia (HSP). Researchers aim to better understand how the disease progresses over time and create a registry for future studies. Participants prov…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC