Paramyxoviridae infectious disease

This study tested two experimental nasal spray vaccines in 24 children aged 2 to 5 years. The vaccines target two viruses that can cause breathing problems: human metapneumovirus (HMPV) and parainfluenza virus type 3 (HPIV3). The main goal was to see if the vaccines are safe and …

This trial investigates how well routine childhood vaccines work in children who have recently finished chemotherapy for cancer. The goal is to see if revaccination can restore protective immunity against diseases like measles, mumps, and whooping cough. Participants receive a se…

This Phase 1 study tests a new vaccine that aims to protect against three respiratory viruses at once: RSV, hMPV, and PIV3. The trial involves 390 adults aged 60 and older and will check if the vaccine is safe and helps the body produce antibodies. Different combinations and dose…

This study tested whether giving a booster polio vaccine (sIPV) at the same time as MMR and hepatitis A vaccines is safe and works well in toddlers. About 889 healthy children aged 18 to 22 months who had already received their first polio and MMR shots took part. Researchers che…

This early-stage study tested the safety and immune response of new vaccines that combine protection against flu, RSV, hMPV, and PIV3 in healthy adults aged 18 to 49. Participants received a single shot of one of several vaccine formulas. The goal was to see if these combination …

This study tested a new measles, mumps, and rubella (MMR) vaccine made by Shanghai Institute of Biological Products in 1,200 healthy children aged 9-11 months. The goal was to see if it works as well as the licensed GSK MMR vaccine and is safe. Children received one dose, and res…

This early-stage trial tested an experimental mRNA vaccine (mRNA-1215) for Nipah virus, a deadly infection with no approved treatments. Forty healthy adults received two doses of the vaccine and were monitored for safety and immune response. The vaccine cannot cause Nipah infecti…

This study tested whether giving monthly nutritional supplements (SQ-LNS) to children aged 6-23 months could increase measles vaccination rates in northern Nigeria. Over 3,800 children participated across 20 wards. The goal was to see if the supplement acted as an incentive for f…

This completed study looked at how measles infection affects children's existing immunity and their ability to respond to vaccines. Researchers enrolled 264 children aged 1-15 in African regions, comparing those with acute measles to healthy controls. Participants received rabies…

This study looked at whether the measles vaccine virus can be found in the breast milk of new mothers who received the MMR vaccine shortly after giving birth. Fourteen breastfeeding women with no immunity to measles or rubella provided milk samples over two weeks. The goal was to…

This study surveyed 99 caregivers of young children in a New York emergency department to find out why some are hesitant about the measles vaccine. Researchers also tested whether a simple message from a doctor could change their minds. The goal is to identify barriers and improv…