Pancreatitis

This trial tests an experimental drug called SGC001 in people who are likely to develop severe acute pancreatitis, a painful inflammation of the pancreas that can lead to organ failure. Participants receive either SGC001 or a placebo as a single intravenous infusion alongside sta…

This trial tests whether a special cooling tube placed near the pancreas can help people with acute pancreatitis recover faster. Participants are randomly assigned to receive either standard care alone or standard care plus the cooling device for up to three days. The study measu…

This phase 2 trial is testing whether pirfenidone, a drug already used for lung scarring, can help people with chronic pancreatitis—a long-term inflammation of the pancreas that causes severe pain. The study will enroll 60 adults with chronic pancreatitis and moderate-to-severe p…

This study tests whether giving the blood thinner heparin early can prevent organ failure in people hospitalized with acute pancreatitis. The inflammation from pancreatitis can cause tiny blood clots that damage organs like the lungs and kidneys. Half of the 100 participants will…

This Phase 3 trial tests an investigational biologic called DR10624, given as a weekly injection, in adults with severe hypertriglyceridemia (very high blood fats) who are already on standard lipid-lowering therapy. The study compares two doses of DR10624 against a placebo to see…

This study looks at 30 people with mild gallstone-related pancreatitis who choose not to have their gallbladder removed. Half will get an ERCP with sphincterotomy (a procedure that opens the bile duct), and half will receive standard care without the procedure. The goal is to see…

This early-phase study tests a surgery that removes the entire pancreas and then transplants the patient's own insulin-making cells into the liver. The goal is to treat chronic pancreatitis and benign tumors while reducing the risk of diabetes. The study includes 12 adults with a…

Pancreatitis is a painful inflammation of the pancreas that can happen after an ERCP procedure. Doctors often give rectal indomethacin around the time of ERCP to lower that risk, but it still occurs. This trial randomly assigns adults having ERCP to receive either rectal indometh…

This trial tests whether a single dose of rectal indomethacin, a common anti-inflammatory drug, can prevent pancreatitis in patients undergoing a bile duct procedure (ERCP) who have had a prior sphincterotomy. About 860 adults will be randomly assigned to receive the drug or no d…

This study tests whether semaglutide (Ozempic/Wegovy) can prevent repeat episodes of acute pancreatitis caused by very high triglycerides. About 396 adults who recently had such an attack will receive either semaglutide injections or a placebo for 18 months, alongside standard ca…

Researchers are testing whether intermittent fasting improves quality of life for adults with acute or chronic pancreatitis. Participants follow a daily 16-hour fast or receive standard calorie guidance. The study measures pancreas-related quality of life, pain, opioid use, weigh…

This study tests whether a thoracic epidural block—a numbing injection near the spine—can help people with severe acute pancreatitis avoid or shorten the need for intensive care support like breathing machines and kidney dialysis. Participants are randomly assigned to receive eit…

This study compares home management versus standard hospital care for people with mild acute pancreatitis. Participants will be randomly assigned to either go home with daily phone check-ins and a clinic visit, or stay in the hospital. The goal is to see if home care is as safe a…

This study tests a special oxygen tube placed in the mouth during a procedure called ERCP, which is used to treat bile duct and pancreas problems. The goal is to see if this method can prevent low oxygen levels that often happen when patients are deeply sedated. About 410 adults …

This study compares an oral carbohydrate solution (a sugar drink) to a standard clear liquid diet as the first food given to people with mild to moderate acute pancreatitis. The goal is to see which approach causes fewer problems like pain or nausea and leads to a shorter hospita…

This study looks at whether routine blood test results can help predict which patients with acute pancreatitis will develop severe disease or die within 28 days. Researchers will track 109 adults admitted with acute pancreatitis and compare their blood cell ratios, such as neutro…

This study looks at adults with acute pancreatitis, a sudden inflammation of the pancreas, to understand the different ways it presents and what happens to patients. Researchers will track 100 participants to identify patterns and potential predictors of outcomes. The goal is to …

This study looks at whether early endoscopic findings in the stomach and duodenum can help predict how severe acute pancreatitis will become. Researchers will perform an upper GI endoscopy within 24-48 hours of hospital admission in 200 adult patients with acute pancreatitis. The…

This study looks at two scoring systems, NEWS-2 and NEWS-Calcium, to see which better predicts the risk of dying in the hospital for people aged 65 and older with acute pancreatitis. Researchers will review medical records of 350 patients to compare the scores. The goal is to hel…

This study will look at whether certain markers from a standard complete blood count (CBC) can help doctors assess how severe acute pancreatitis is and predict patient outcomes. Researchers will analyze data from 100 adult patients treated for acute pancreatitis. The goal is to s…

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…