Palmoplantar keratosis
MONDO:0006590A group of autosomal dominant, autosomal recessive, X-linked inherited or acquired disorders characterized by the thickening of the palms and soles due to hyperkeratosis.
Also known as: palmoplantar keratoderma, keratoderma, palmoplantar
16 clinical trials for this condition and its sub-types, 4 tagged with Palmoplantar keratosis itself.
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Sub-types of Palmoplantar keratosis
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Hereditary palmoplantar keratoderma 0 trials · 13 incl. sub-types
8 sub-types
- Diffuse palmoplantar keratoderma 0 trials · 12 incl. sub-types Sub-types →
- Olmsted syndrome 1 trial Sub-types →
- Focal palmoplantar keratoderma 0 trials · 1 incl. sub-types Sub-types →
- Palmoplantar keratoderma, epidermolytic 0 trials · 1 incl. sub-types Sub-types →
- Alopecia congenita keratosis palmoplantaris 0 trials
- Palmoplantar keratoderma i, striate, focal, or diffuse 0 trials
- Palmoplantar keratoderma, nonepidermolytic, focal or diffuse 0 trials
- Punctate palmoplantar keratoderma 0 trials Sub-types →
Most studied deeper sub-types
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Could a psoriasis drug help thickened hands and feet?
Disease control OngoingThis study tests a daily cream called tapinarof, already used for psoriasis, in 6 adults with palmoplantar keratoderma — a condition that causes painful thickening of skin on the palms and soles. Researchers want to see if the cream can clear or improve the skin and check for sid…
Phase 2 • Sponsor: Indiana University • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New hope for ALS patients: experimental drug CNM-Au8 now available through expanded access
Disease control Expanded access (paused)This program provides early access to an experimental drug called CNM-Au8 for people with amyotrophic lateral sclerosis (ALS), a progressive nerve disease. Participants must be 18 or older and have a confirmed ALS diagnosis. The goal is to offer treatment to those who cannot join…
Sponsor: Clene Nanomedicine • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Desperate patient gets experimental stem cells for rare nerve disease
Disease control Expanded access (ended)This study provides an experimental stem cell treatment (HB-adMSCs) to an 83-year-old man with Primary Lateral Sclerosis, a rare nerve disease that causes progressive muscle weakness. The patient's own banked stem cells are used, aiming to slow the disease. This is a single-patie…
Sponsor: Hope Biosciences Research Foundation • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC