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Osteogenesis imperfecta type 1
MONDO:0008146Osteogenesis imperfecta type I is a mild type of osteogenesis imperfecta (OI), a genetic disorder characterized by increased bone fragility, low bone mass and susceptibility to bone fractures.
Also known as: Adair-Dighton syndrome, COL1A1-related osteogenesis imperfecta, OI type 1, OI1, Van der Hoeve syndrome, mild osteogenesis imperfecta, non-deforming osteogenesis imperfecta, osteogenesis imperfecta type 1
8 clinical trials for this condition and its sub-types, 8 tagged with Osteogenesis imperfecta type 1 itself.
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Browse by category →Sub-types of Osteogenesis imperfecta type 1
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New shot aims to fortify fragile bones in brittle bone disease trial
Disease control Recruiting nowThis study tests a drug called AGA2115 in 80 adults with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. Participants receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug increases bone density in the spine after 1…
Phase 2 • Sponsor: Angitia Incorporated Limited • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New shot aims to toughen fragile bones in rare disease
Disease control Recruiting nowThis phase 2 trial tests a drug called AGA2115 in 48 Chinese adults and adolescents with osteogenesis imperfecta (types I, III, IV), a condition that makes bones brittle. Participants receive one of three dose schedules by injection under the skin. The study checks for side effec…
Phase 2 • Sponsor: Angitia Biopharmaceuticals Guangzhou Limited • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Brittle bone breakthrough? drug may restore hearing
Disease control Recruiting nowThis study tests whether bisphosphonates, drugs commonly used to strengthen bones, can also treat hearing loss in people with Osteogenesis Imperfecta (OI) type I. Researchers will enroll 100 adults and children with OI, giving some the drug and comparing their hearing over time. …
Phase 4 • Sponsor: Hospital for Special Surgery, New York • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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Gentle exercise with cuffs may strengthen bones and muscles in brittle bone disease
Symptom relief Recruiting nowThis study tests a safe, low-intensity exercise program using inflatable cuffs on the legs to improve muscle, bone, and quality of life in 40 adults with osteogenesis imperfecta type I (a mild form of brittle bone disease). Participants will do simple home exercises 2-3 times a w…
Sponsor: University Hospital, Ghent • Aim: Symptom relief
Last updated Jun 27, 2026 11:02 UTC