Oral cavity carcinoma
MONDO:0044925A carcinoma arising in the oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma.
Also known as: oral cavity cancer, carcinoma of mouth, carcinoma of oral cavity, carcinoma of the oral cavity, mouth carcinoma, oral cavity carcinoma
3147 clinical trials for this condition and its sub-types, 16 tagged with Oral cavity carcinoma itself.
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Sub-types of Oral cavity carcinoma
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Oral cavity squamous cell carcinoma 139 trials · 154 incl. sub-types
7 sub-types
- Tongue squamous cell carcinoma 9 trials · 13 incl. sub-types Sub-types →
- Salivary gland squamous cell carcinoma 4 trials Sub-types →
- Verrucous carcinoma of oral cavity 3 trials
- Squamous cell carcinoma of buccal mucosa 2 trials
- Squamous cell carcinoma of floor of mouth 2 trials
- Squamous cell carcinoma of lip 2 trials
- Maxillary sinus squamous cell carcinoma 1 trial
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Salivary gland carcinoma 26 trials · 36 incl. sub-types
13 sub-types
- Major salivary gland carcinoma 6 trials Sub-types →
- Salivary gland squamous cell carcinoma 4 trials Sub-types →
- Salivary duct carcinoma 3 trials
- Salivary gland adenoid cystic carcinoma 3 trials Sub-types →
- Mammary analog secretory carcinoma 0 trials
- Minor salivary gland carcinoma 0 trials Sub-types →
- Salivary gland basal cell adenocarcinoma 0 trials
- Salivary gland carcinoma ex pleomorphic adenoma 0 trials Sub-types →
- Salivary gland epithelial myoepithelial carcinoma 0 trials
- Salivary gland large cell carcinoma 0 trials
- Salivary gland mucinous adenocarcinoma 0 trials
- Salivary gland mucoepidermoid carcinoma 0 trials Sub-types →
- Salivary gland small cell carcinoma 0 trials
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Oral cavity carcinoma in situ 5 trials
1 sub-type
- Lip carcinoma in situ 0 trials
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Tongue carcinoma 4 trials
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Carcinoma of lip 0 trials · 2 incl. sub-types
2 sub-types
- Squamous cell carcinoma of lip 2 trials
- Lip carcinoma in situ 0 trials
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Carcinoma of hard palate 1 trial
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Carcinoma of soft palate 1 trial
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Intraoral basal cell carcinoma 0 trials
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Oral cavity mucoepidermoid carcinoma 0 trials
2 sub-types
Most studied deeper sub-types
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Can heat boost chemo? early trial tests thermotherapy for head and neck cancer
Disease control Recruiting nowThis early-phase trial tests whether adding mild heat therapy (thermotherapy) to standard chemoradiation is safe and tolerable for people with advanced head and neck cancer. The heat, applied once a week, aims to make the cancer more sensitive to treatment. The study includes two…
Phase 1 • Sponsor: Erasmus Medical Center • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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Could skipping the flap during radiation reduce side effects without harming cancer control?
Disease control Recruiting nowThis study tests whether avoiding radiation to the surgical flap (the tissue used to rebuild the mouth after cancer removal) is as effective as standard radiation that treats the whole area. About 348 adults with oral cavity cancer who had reconstructive surgery will be randomly …
Phase 3 • Sponsor: Centre Francois Baclesse • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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Pill combo offers new hope for rural head and neck cancer patients
Disease control Recruiting nowThis study is testing whether taking three oral chemotherapy drugs together is safe and practical for patients with head and neck cancer that has returned or spread. The trial focuses on people living in rural Midwest areas, making it easier for them to participate from home. The…
Phase 2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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New injection fights head and neck cancer from the inside
Disease control Recruiting nowThis early-stage trial tests a new treatment called VLPONC-01, which is injected directly into head and neck tumors. It delivers a substance (IL-12) that may help the immune system attack the cancer. Some participants will also receive the immunotherapy drug pembrolizumab. The ma…
Phase 1 • Sponsor: VLP Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Could oral cancer surgery become a Same-Day procedure?
Disease control Recruiting nowThis pilot study is testing whether people with early-stage oral or throat cancer (T1-N0 or T2-N0) can safely have their tumor removed as an outpatient, going home the same day. The procedure also includes a sentinel lymph node biopsy to check for cancer spread. Researchers will …
Sponsor: University Hospital, Montpellier • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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3D-Printed mouth guards could ease radiation side effects for cancer patients
Symptom relief Recruiting nowThis study tests whether custom 3D-printed oral stents can reduce mouth sores in head and neck cancer patients receiving radiation therapy. The stents are made from a mold of the patient's mouth and cover teeth and gums during treatment. Researchers will compare sore rates and pa…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Can a single drink reveal how alcohol triggers oral cancer?
Knowledge-focused Recruiting nowThis study investigates how acetaldehyde, a byproduct of alcohol, affects cells in the mouth and whether it may increase oral cancer risk. Healthy volunteers and individuals with Fanconi anemia (a condition linked to higher cancer risk) will consume a single dose of alcohol and p…
Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Knowledge-focused
Last updated Jul 24, 2026 00:00 UTC