Nonobstructive coronary artery disease

This study tests whether a drug called Brezavvy (an SGLT2 inhibitor) can improve blood flow in the tiny vessels of the heart and reduce chest pain in women who have angina but no blocked major arteries. 150 women will take either the drug or a placebo for 12 weeks and undergo hea…

This study tests whether doing a follow-up CT scan of the heart arteries in people with non-obstructive coronary artery disease can help doctors adjust treatment to better control cholesterol and prevent heart attacks, strokes, or death. About 3,100 participants will be randomly …

This study aims to create a non-invasive diagnostic algorithm using PET imaging and CT scans to identify microvascular angina in patients who have chest pain and signs of ischemia but no blocked coronary arteries. About 70 participants with symptoms of angina or shortness of brea…

This study tests whether a magnetocardiography (MCG) device can detect reduced blood flow to the heart muscle in people with acute chest pain but no major artery blockages. About 3,786 participants will undergo MCG scanning, and results will be compared to a standard ultrasound t…

This study looks at whether giving a nitrate drug during a heart test can better detect blood flow problems in people who have chest pain but no blocked arteries. About 50 adults will get the standard test, then a repeat test after nitrates. The goal is to see if nitrates improve…

This study is testing whether a special heart scan (SPECT) can detect problems in the heart's smallest blood vessels, called microvascular dysfunction. Researchers will measure how the heart muscle moves and pumps blood in 75 people with and without coronary artery disease. The g…

This study tests a 3-month mobile health cardiac rehab program for people with INOCA (chest pain or ischemia without blocked arteries). Participants use an activity tracker, log exercise, and get weekly coaching. The goal is to see if this approach improves symptoms, daily functi…

This study will enroll 246 people who have had a heart stent but still experience chest pain. Researchers will use a detailed diagnostic approach during a heart catheterization to identify whether the pain is due to new blockages, incomplete treatment, or other issues. The goal i…

This study looks at people who have chest pain but no major blockages in their heart arteries. Researchers will test if giving medication based on the specific type of tiny blood vessel problem (endotype) works better than standard care. About 180 participants will be followed fo…

This study looks at people with chest pain (angina) but no major blockages in their heart arteries. During a standard angiogram, doctors will perform an extra diagnostic test to see if it helps guide treatment. Half the participants will have the test results shared with their do…

This study looks at whether simple, non-invasive skin tests can detect early signs of heart disease by measuring how well small blood vessels work. Researchers will study 900 people aged 60-75, comparing skin blood flow measurements with detailed heart scans. The goal is to find …

This study looks at why people with angina but no blocked arteries (ANOCA) often have poor fitness. Researchers will test whether a 4-week, remotely supervised high-intensity interval training (HIIT) program can safely improve heart function, exercise capacity, and quality of lif…