Nonobstructive coronary artery disease

This trial tests whether dapagliflozin, a drug used for diabetes, can improve blood flow in the tiny vessels of the heart in people with angina (chest pain) but no blocked coronary arteries. Participants will take either dapagliflozin or a placebo daily for 180 days. The study me…

This pilot study checks if a bigger trial on low-dose aspirin for people with early, symptom-free coronary artery disease can be done. It will enroll 48 adults with signs of artery narrowing but no symptoms. The main goal is to see if doctors can recruit enough patients and if pa…

This study tests whether an artificial intelligence system called AngioAI+ can accurately diagnose two types of coronary artery disease using standard angiogram images. The research involves 620 adults with suspected coronary artery disease who are already scheduled for an angiog…

This study looks at whether a non-invasive ultrasound of the heart can diagnose blood vessel problems in people with chest pain but no blocked arteries. About 35 patients who previously had an invasive heart test will get an ultrasound instead. The goal is to see if the ultrasoun…

This trial tests whether an 8-week daily resistance exercise program can reduce chest pain and improve daily function in women who have angina without blocked coronary arteries (ANOCA). Around 76 to 152 women across 13 hospitals in the UK and Netherlands will be randomly assigned…

This study builds a registry of 400 women who have angina, or chest pain, even though their coronary arteries are not blocked. Doctors call this condition ANOCA, and it is more common in women than men, yet it has been under-studied. The registry will categorize different subtype…

This study will examine 250 adults with chest pain but no major blockages in their heart arteries (a condition called INOCA). Researchers will collect cells from the heart's blood vessels during a standard angiogram and track symptoms, activity, and function over one year using q…