Why do some people have chest pain without blocked arteries? new study aims to find out
NCT ID NCT07586241
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will examine 250 adults with chest pain but no major blockages in their heart arteries (a condition called INOCA). Researchers will collect cells from the heart's blood vessels during a standard angiogram and track symptoms, activity, and function over one year using questionnaires and a Fitbit. The goal is to understand how blood vessel inflammation relates to chest pain and daily life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors better understand why some people have chest pain without blocked arteries, potentially leading to improved diagnosis or treatment approaches.
- What could go wrong
- This is an observational study that does not test a new treatment, so it will not directly improve patient outcomes. Results may not lead to immediate changes in care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 250 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2031
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult men and women age ≥18 with suspected INOCA who are planned to undergo clinically indicated coronary function testing.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adult age ≥18 years referred for clinically indicated coronary angiography 2. Chronic coronary disease or potentially ischemic symptoms as the indication for coronary angiography 3. Possible or suspected ischemia with non-obstructive epicardial coronary arteries (INOCA) Exclusion Criteria: Clinical (Pre-Cath) Exclusion criteria: 1. Anemia (hemoglobin \<9 mg/dl) 2. Severe valvular heart disease 3. Acute myocardial infarction within 30 days 4. Severe valvular heart disease 5. New York Heart Association (NYHA) Functional Class III or IV heart failure 6. Hypertrophic obstructive cardiomyopathy or severe left ventricular hypertrophy 7. Pregnancy (because of potential exercise/activity limitations and symptom changes)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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NYU Langone Health
New York, New York, 10016, United States