New-onset refractory status epilepticus
MONDO:0018199New-onset refractory status epilepticus is an acute encephalopathy with inflammation-mediated status epilepticus characterized by an acute refractory status epilepticus, typically of the tonic-clonic type, following prodromal symptoms of confusion, fever, fatigue, headache, symptoms of gastrointestinal or upper respiratory tract infection, behavioral changes or hallucinations. Brain MRI abnormalities and abnormal findings in CSF, including pleocytosis and/or elevated protein levels, are frequently found during acute episode. Treatment-resistant epilepsy, cognitive and psychiatric impairments are usual consequences.
Also known as: NORSE, Norse, De novo cryptogenic refractory multifocal febrile status epilepticus, New onset refractory status epilepticus
16 clinical trials for this condition and its sub-types, 8 tagged with New-onset refractory status epilepticus itself.
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Could a drug combo stop seizures faster? new trial tests the idea
Disease control CompletedThis phase 3 trial tested whether giving two anti-seizure drugs together (levetiracetam plus clonazepam) works better than clonazepam alone for stopping prolonged seizures in the ambulance or at home. 203 adults with generalized tonic-clonic status epilepticus took part. The main…
Phase 3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Anesthetic gas may tame stubborn seizures when other drugs fail
Disease control CompletedThis study reviewed medical records of 66 adults in intensive care who received the anesthetic gas isoflurane for severe seizures that didn't respond to standard treatments. Researchers wanted to see how often isoflurane stopped the seizures or led to full awakening. The goal is …
Sponsor: Hopital of Melun • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Routine EEGs may hold hidden clues to childhood epilepsy — a new analysis method is put to the test
Diagnosis CompletedThis study is testing whether a computer tool called BioEP can detect signs of seizure susceptibility in standard EEG recordings from children with epilepsy. Researchers will analyze past EEGs from 530 children aged 2 to 18 who already have an epilepsy diagnosis. The goal is to s…
Sponsor: Neuronostics Ltd • Aim: Diagnosis
Last updated Aug 01, 2026 00:00 UTC