Could a drug combo stop seizures faster? new trial tests the idea
NCT ID NCT01150331
First seen Jan 18, 2026 · Last updated Jun 23, 2026 · Updated 22 times
Summary
This phase 3 trial tested whether giving two anti-seizure drugs together (levetiracetam plus clonazepam) works better than clonazepam alone for stopping prolonged seizures in the ambulance or at home. 203 adults with generalized tonic-clonic status epilepticus took part. The main goal was to see if seizures stopped within 15 minutes after the injection.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Necker Hospital
Paris, 75015, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
levetiracetam and clonazepam (anti-seizure drugs)
What this could lead to
If it works, this could point toward a more effective first-line treatment for stopping prolonged seizures before reaching the hospital.
What could go wrong
This trial is completed but results are not yet widely confirmed. Adding levetiracetam may not improve outcomes over clonazepam alone, and both drugs carry risks like drowsiness or breathing problems.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.