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Anesthetic gas may tame stubborn seizures when other drugs fail

NCT ID NCT05830864

Disease control Sponsor: Hopital of Melun Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study reviewed medical records of 66 adults in intensive care who received the anesthetic gas isoflurane for severe seizures that didn't respond to standard treatments. Researchers wanted to see how often isoflurane stopped the seizures or led to full awakening. The goal is to find a backup option for these life-threatening situations.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Isoflurane (an inhaled anesthetic)
What this could lead to
If results are positive, isoflurane could become a reliable option to stop prolonged seizures when other treatments fail.
What could go wrong
This is a small, retrospective review (66 patients), not a controlled trial, so results may not prove cause and effect. Isoflurane is an anesthetic with risks like low blood pressure and breathing problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

66 people

The number who actually took part.

Started

Jun 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients with eligibility criteria in the sites of study will be included int the study

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years, hospitalized in ICU between 2016-01-01 and 2023-01-01, suffering refractory status epilepticus treated by inhaled Isoflurane as third anticonvulsive therapy Exclusion Criteria: * post-anoxic refractory status epilepticus after cardiac arrest, withdrawal of consent for medical data use

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Conditions

The condition(s) this trial relates to.

new-onset refractory status epilepticus Status Epilepticus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Refractory status epilepticus

Contacts and locations

Locations

  • CH Toulon - Sainte Musse

    Toulon, 83000, France

  • CHU Brest

    Brest, 29200, France

  • Ch Bethune Beuvry

    Beuvry, 62660, France

  • GH Sud Ile de France, Hôpital de Melun-Sénart

    Melun, 77000, France

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