Myasthenia gravis

This trial is testing an investigational drug called rozanolixizumab in people with generalized myasthenia gravis, a condition that causes muscle weakness. The study aims to see if repeated treatment cycles are safe and can help improve daily functioning. Participants receive the…

This trial is investigating whether rozanolixizumab, an experimental drug given as a subcutaneous infusion, is safe and effective over the long term for adults with generalized myasthenia gravis, a chronic condition causing muscle weakness. Participants who completed a prior stud…

This study tested a drug called rozanolixizumab in 200 adults with generalized myasthenia gravis, a condition that causes muscle weakness. The goal was to see if the drug improves daily activities and is safe compared to a placebo. Participants received either the drug or a dummy…

This study tests the long-term safety and effectiveness of zilucoplan, a daily injection, in people with generalized myasthenia gravis (gMG), a condition that causes muscle weakness. About 200 participants who completed a prior zilucoplan trial will receive the drug for an extend…

This study tested an experimental drug called RC18 in 29 adults with systemic myasthenia gravis, a condition that causes muscle weakness. The goal was to see if RC18 is safe and can help control symptoms. Participants received the drug while continuing their usual treatments, and…

This study tested two different ways of giving the drug efgartigimod to people with generalized myasthenia gravis, a condition that causes muscle weakness. One group received the drug continuously, while the other got it in cycles. The goal was to see which schedule works better …

This study looked at the long-term safety of a drug called HBM9161 for people with generalized myasthenia gravis, a condition that causes muscle weakness. It involved 111 patients who had already completed a previous phase 3 study. The goal was to see if the drug is safe to use o…

This study compares two treatments—intravenous immunoglobulin (IVIG) and plasma exchange (PLEX)—for people experiencing a myasthenic crisis, a severe episode of muscle weakness in myasthenia gravis. Fifty adults were treated with either IVIG or PLEX, and their improvement was mea…

This study tested whether people with generalized myasthenia gravis (gMG) can safely and effectively use an auto-injector to give themselves the drug zilucoplan at home. Thirty-one adults who were already on a stable dose of zilucoplan took part. The main goal was to see if they …

This study looked at whether a modified traditional Chinese herbal formula, Guilu Erxian Glue, can help people with myasthenia gravis (a disease causing muscle weakness). Researchers reviewed medical records of 231 patients who took the herbal formula alongside standard Western m…

This study tested the long-term safety of efgartigimod injections in 184 people with generalized myasthenia gravis, a chronic disease that causes muscle weakness. Participants received repeated treatment cycles over time. The goal was to see if the drug is safe and tolerable when…

This completed Phase 3 study tested eculizumab in 15 Chinese patients with refractory generalized myasthenia gravis (gMG), a condition where standard treatments fail. Eculizumab is given by IV infusion and aims to improve daily living activities and muscle strength. The study mea…

This early-stage study tested a new cell therapy called MuSK-CAART in 7 people with a rare, severe form of myasthenia gravis (MuSK MG). The treatment uses a patient's own immune cells, modified to attack the harmful antibodies causing the disease. The main goal was to check safet…

This pilot study tested the drug tofacitinib in 19 adults with refractory myasthenia gravis, a condition where standard treatments fail. Participants took a 5 mg tablet twice daily for 4 months, followed by a 1-month washout. The study measured changes in muscle strength and dail…

This study tested whether people with generalized myasthenia gravis could safely switch from intravenous (IV) infusions of complement inhibitors to daily injections of zilucoplan. Twenty-six participants who were stable on IV therapy switched to the subcutaneous shot. The main fo…

This trial tests whether proprioceptive neuromuscular facilitation exercises, a type of movement therapy that uses resistance and sensory cues, can reduce fatigue and improve muscle strength and daily function in people with myasthenia gravis. About 23 adults with stable generali…

This study looked at whether having a tendency toward depression affects how well people with thymoma-associated myasthenia gravis (MG) respond to psychological counseling. Nineteen adults who had surgery for thymoma and MG received eight sessions of counseling based on Gestalt t…

This study tested an online program to improve mental health in people with myasthenia gravis, a chronic muscle weakness condition. 77 patients completed a four-month program of short videos on Facebook about building social support, emotional awareness, and self-worth. Researche…

This study tested whether 62 people with generalized myasthenia gravis could learn to self-administer the drug rozanolixizumab at home using a syringe driver or manual push. Participants were trained and then assessed on their ability to correctly give themselves the infusion. Th…

This study tested whether acupuncture can improve quality of life and daily activities for people with myasthenia gravis, a condition that causes muscle weakness. Twenty-four adults received acupuncture twice a week for 12 weeks, with some starting immediately and others after a …

This study looked at how well two drugs, azathioprine and mycophenolate mofetil, work for people with myasthenia gravis in everyday medical practice. Researchers followed 82 adults with autoimmune MG for 2-3 years, measuring quality of life and side effects. The goal was to provi…

This completed study enrolled 311 people with myasthenia gravis, a condition that causes muscle weakness. Researchers collected clinical information and blood samples to build a repository for future studies. The goal is to help scientists better understand the disease and potent…

This completed study looked at how common cognitive (thinking) difficulties are in 150 people with myasthenia gravis. Researchers measured memory, attention, and other mental skills, and how these issues affect daily activities, work, and quality of life. The goal is to better un…

This study reviewed medical records of 100 people with myasthenia gravis who had thymus gland surgery. Researchers compared those with and without a thymus tumor to see what factors helped predict a full recovery. The goal was to better understand who benefits most from this proc…

This study tested a new sustained-release (long-acting) version of pyridostigmine, a drug used for myasthenia gravis (a muscle weakness disease). Forty healthy Chinese adults took both the new long-acting tablet and the standard immediate-release tablet at different times to comp…