Movement disorder
MONDO:0005395Neurological conditions resulting in abnormal voluntary or involuntary movement, which may impact the speed, fluency, quality and ease of movement.
Also known as: movement disease, movement disorder, movement disorders
805 clinical trials for this condition and its sub-types, 108 tagged with Movement disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Movement disorder
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Extrapyramidal and movement disease 0 trials · 149 incl. sub-types
1 sub-type
- Dystonic disorder 65 trials · 149 incl. sub-types Sub-types →
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Cerebellar ataxia 40 trials · 144 incl. sub-types
1 sub-type
- Hereditary cerebellar ataxia 0 trials · 116 incl. sub-types Sub-types →
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Multiple system atrophy 110 trials · 119 incl. sub-types
4 sub-types
- Pure autonomic failure 18 trials
- Multiple system atrophy, parkinsonian type 12 trials
- Multiple system atrophy, cerebellar type 3 trials
- Striatonigral degeneration 0 trials Sub-types →
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Essential tremor 102 trials · 104 incl. sub-types
6 sub-types
- Tremor, hereditary essential, 1 2 trials
- Tremor, hereditary essential, 2 0 trials
- Tremor, hereditary essential, 3 0 trials
- Tremor, hereditary essential, 4 0 trials
- Tremor, hereditary essential, 5 0 trials
- Tremor, hereditary essential, 6 0 trials
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Progressive supranuclear palsy 73 trials · 77 incl. sub-types
4 sub-types
- Supranuclear palsy, progressive, 1 5 trials
- Atypical progressive supranuclear palsy syndrome 1 trial · 4 incl. sub-types Sub-types →
- Supranuclear palsy, progressive, 2 0 trials
- Supranuclear palsy, progressive, 3 0 trials
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Huntington disease 76 trials
2 sub-types
- Juvenile Huntington disease 1 trial
- Westphal disease 0 trials
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Progressive non-fluent aphasia 23 trials · 44 incl. sub-types
1 sub-type
- Semantic dementia 32 trials Sub-types →
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Behavioral variant of frontotemporal dementia 21 trials · 42 incl. sub-types
3 sub-types
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Tourette syndrome 41 trials
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Corticobasal syndrome 19 trials
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Frontotemporal dementia with motor neuron disease 13 trials · 19 incl. sub-types
7 sub-types
- Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 5 trials
- Amyotrophic lateral sclerosis type 10 3 trials
- Amyotrophic lateral sclerosis type 6 1 trial
- Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 0 trials
- Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 0 trials
- Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 0 trials
- Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 0 trials
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Chronic tic disorder 15 trials
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Choreatic disease 11 trials
5 sub-types
- Chorea gravidarum 0 trials
- Chorea, benign familial 0 trials
- Chorea, remitting, with nystagmus and cataract 0 trials
- Choreoathetosis, familial inverted 0 trials
- Hereditary progressive chorea without dementia 0 trials
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Neurodegeneration with brain iron accumulation 1 trial · 8 incl. sub-types
14 sub-types
- Neurodegeneration with brain iron accumulation 5 4 trials
- Pantothenate kinase-associated neurodegeneration 4 trials Sub-types →
- PLA2G6-associated neurodegeneration 1 trial Sub-types →
- Kufor-Rakeb syndrome 0 trials Sub-types →
- Woodhouse-Sakati syndrome 0 trials
- Aceruloplasminemia 0 trials
- Early-onset progressive encephalopathy-spastic ataxia-distal spinal muscular atrophy syndrome 0 trials
- Fatty acid hydroxylase-associated neurodegeneration 0 trials
- Neurodegeneration with brain iron accumulation 4 0 trials
- Neurodegeneration with brain iron accumulation 6 0 trials
- Neurodegeneration with brain iron accumulation 7 0 trials
- Neurodegeneration with brain iron accumulation 8 0 trials
- Neurodegeneration with brain iron accumulation 9 0 trials
- Neuroferritinopathy 0 trials
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Arthrogryposis 4 trials · 6 incl. sub-types
5 sub-types
- Freeman-Sheldon syndrome 1 trial Sub-types →
- Congenital contractural arachnodactyly 1 trial
- Boylan dew greco syndrome 0 trials
- Distal arthrogryposis Moore weaver type 0 trials
- Massa casaer ceulemans syndrome 0 trials
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Inherited Creutzfeldt-Jakob disease 5 trials
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Primary orthostatic tremor 5 trials
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Clonic hemifacial spasm 4 trials
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Familial congenital mirror movements 3 trials
4 sub-types
- Mirror movements 1 and/or agenesis of the corpus callosum 0 trials Sub-types →
- Mirror movements 2 0 trials
- Mirror movements 3 0 trials
- Mirror movements 4 0 trials
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Transient tic disorder 3 trials
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Opsoclonus-myoclonus syndrome 2 trials
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Lafora disease 1 trial
2 sub-types
- Myoclonic epilepsy of Lafora 1 0 trials
- Myoclonic epilepsy of Lafora 2 0 trials
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Unverricht-Lundborg syndrome 1 trial
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Benign shuddering attacks 1 trial
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Myoclonus, familial 1 trial
2 sub-types
- Myoclonus, familial, 1 0 trials
- Myoclonus, familial, 2 0 trials
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Psychogenic movement disorders 1 trial
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PRRT2-associated paroxysmal movement disorder 0 trials · 1 incl. sub-types
3 sub-types
- Episodic kinesigenic dyskinesia 1 1 trial
- Infantile convulsions and choreoathetosis 0 trials
- Seizures, benign familial infantile, 2 0 trials
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Intellectual disability-hyperkinetic movement-truncal ataxia syndrome 0 trials · 1 incl. sub-types
1 sub-type
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Huntington disease-like 3 0 trials
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2 sub-types
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Sandifer syndrome 0 trials
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Brain-lung-thyroid syndrome 0 trials
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1 sub-type
- Torsion dystonia 2 0 trials
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Epilepsy with myoclonic absences 0 trials
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Hereditary geniospasm 0 trials
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Hyperekplexia 0 trials
2 sub-types
- Hereditary hyperekplexia 0 trials Sub-types →
- Sporadic hyperekplexia 0 trials
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Isolated facial myokymia 0 trials
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Kuru 0 trials
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Lingual-facial-buccal dyskinesia 0 trials
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Neuroacanthocytosis 0 trials
2 sub-types
- VPS13A-related neurodegenerative disease 0 trials
- XK-related neurodegenerative disease 0 trials
Most studied deeper sub-types
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Free drug access for Parkinson's patients with specific gene mutation
Disease control Expanded access (ended)This program offers continued free access to the experimental drug BIA 28-6156 for people with Parkinson's disease who have a specific change in the GBA1 gene and have already completed the ACTIVATE study. Participants take one 60mg pill daily. The goal is to provide ongoing trea…
Sponsor: Bial R&D Investments, S.A. • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Can a dopamine-blocking drug safely control tourette syndrome over years?
Disease control OngoingThis trial investigates the long-term safety of ecopipam, a drug that blocks dopamine D1 and D5 receptors, in children, adolescents, and adults with Tourette syndrome. Participants who completed a prior study may enroll and receive ecopipam for up to 24 weeks or longer. The main …
Phase 3 • Sponsor: Emalex Biosciences Inc. • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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Promising new drug targets genetic Parkinson's in early trial
Disease control OngoingThis study tests an experimental drug called BIIB122 in 50 people who have a specific genetic form of Parkinson's disease (LRRK2-PD). The main goal is to check the drug's safety and how it affects certain markers in the blood and urine over 12 weeks. Participants are randomly ass…
Phase 2 • Sponsor: Denali Therapeutics Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New pill aims to slow Parkinson's in patients with genetic mutation
Disease control OngoingThis study tests an experimental drug called BIA 28-6156 in people with Parkinson's disease who have a specific change in the GBA1 gene. The goal is to see if the drug can delay the worsening of movement-related daily living skills over 78 weeks. About 237 participants will recei…
Phase 2 • Sponsor: Bial R&D Investments, S.A. • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Brain injection aims to slow Huntington's
Disease control OngoingThis early-stage study tests a gene therapy called AB-1001 in 5 adults with early Huntington's disease. The treatment is injected directly into the brain to potentially slow the disease. The main goal is to check safety, but researchers will also look at brain changes on MRI and …
Phase 1/2 • Sponsor: AskBio France, SAS, a subsidiary of AskBio Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New gel pump for Parkinson's: Real-World results under scrutiny
Disease control OngoingThis study follows about 300 adults with advanced Parkinson's who are already using Lecigon, a gel given through a pump to control movement problems. Researchers will track how well it works and what side effects occur over up to two years in everyday medical care. The goal is to…
Sponsor: Britannia Pharmaceuticals Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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AI and home videos could spot cerebral palsy months earlier
Diagnosis OngoingThis study explores whether a new screening procedure can detect cerebral palsy (CP) earlier in high-risk infants using video recordings and artificial intelligence. Traditionally, CP is diagnosed between 12 and 24 months of age, but earlier detection could lead to better outcome…
Sponsor: St. Olavs Hospital • Aim: Diagnosis
Last updated Jul 23, 2026 00:00 UTC
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Super-Sharp brain scanner could revolutionize diagnosis of dementia and cancer
Diagnosis By invitation onlyThis study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…
Sponsor: prof. dr. Koen Van Laere • Aim: Diagnosis
Last updated Jun 27, 2026 12:36 UTC
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New pill aims to steady shaking hands in essential tremor trial
Symptom relief OngoingThis study tests whether a new drug called ulixacaltamide can safely reduce tremors and improve daily activities in adults with essential tremor. About 1,000 participants will receive either the drug or a placebo for up to 12 weeks, then may join a long-term safety study. The goa…
Phase 3 • Sponsor: Praxis Precision Medicines • Aim: Symptom relief
Last updated Jul 18, 2026 00:00 UTC
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Could a simple ear device ease Parkinson's symptoms?
Symptom relief By invitation onlyThis study tests a non-invasive device that stimulates a nerve in the ear to see if it can improve movement, mood, sleep, and motivation in people with Parkinson's disease. Thirty participants will try three different stimulation patterns over several weeks. The goal is to find t…
Sponsor: Anhui Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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A Baby's fidgets may reveal brain health: study tests early warning signs
Knowledge-focused OngoingResearchers are studying the natural fidgety movements of infants to see if these movements can help predict cerebral palsy and other developmental issues. They will follow 350 babies, including healthy full-term infants and those at higher risk due to medical conditions, trackin…
Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago • Aim: Knowledge-focused
Last updated Sep 05, 2026 00:00 UTC
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Can a quick bike ride boost brain power? new study investigates
Knowledge-focused OngoingThis study looks at how short bursts of aerobic exercise affect brain function in older adults and stroke survivors. Researchers will compare three groups: one doing moderate cycling to raise lactate levels, one doing light cycling, and one receiving health education only. Partic…
Sponsor: University of Alabama at Birmingham • Aim: Knowledge-focused
Last updated Jul 19, 2026 00:00 UTC
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Can brain recordings make DBS safer for thinking and memory?
Knowledge-focused OngoingThis study tracks brain activity in 160 Parkinson's patients who have or will receive deep brain stimulation (DBS). Researchers record signals from the brain during memory tasks, with the stimulator on and off, to find patterns linked to cognitive side effects. The goal is to ide…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Global brain surgery matchmaker aims to help kids with rare movement disorders
Knowledge-focused By invitation onlyThis study is building an online platform called DBS MatchMaker to connect doctors around the world who treat rare movement disorders with deep brain stimulation (DBS). The goal is to help doctors share knowledge and find the best ways to treat patients. Up to 500 people of all a…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Brain pacemaker study seeks better patterns for movement disorders
Knowledge-focused By invitation onlyThis study looks at how different patterns of deep brain stimulation (DBS) affect movement symptoms and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test non-regular stimulation patterns to find ways to mak…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Can a simple camera replace fancy Motion-Capture suits?
Knowledge-focused OngoingThis study tested whether a markerless motion analysis system (OpenPose) can accurately measure walking patterns compared to a standard optoelectronic system that uses markers. Researchers recorded 25 people (ages 4 and up) with various motor impairments while they walked. The go…
Sponsor: IRCCS Eugenio Medea • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Meditation brain study in Parkinson's withdrawn before starting
Knowledge-focused CancelledThis study planned to use brain scans to measure how a meditation technique called OM affects dopamine and stress markers in people with Parkinson's disease. It was withdrawn before enrolling any participants, so no results are available. The goal was to better understand meditat…
Phase 2 • Sponsor: Andrew Newberg • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:00 UTC