Mixed anxiety and depressive disorder
MONDO:0041086Also known as: mixed anxiety and depressive disorder, anxiety depression
192 clinical trials for this condition and its sub-types, 97 tagged with Mixed anxiety and depressive disorder itself.
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Compassion training may ease teacher burnout and mental distress
Disease control CompletedThis study tests a program called Compassionate Mind Training for Teachers (CMT-T) to see if it can reduce depression, anxiety, and self-criticism in elementary school teachers. Forty teachers from public schools in Aracaju, Brazil, will take part in group sessions that include m…
Sponsor: Universidade Federal de Sergipe • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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Can two antipsychotics together tame schizophrenia better?
Disease control CompletedThis study looked at 6 people with schizophrenia who were already taking a combination of two long-acting injectable medications: Abilify Maintena and Rexulti. Researchers tracked their symptoms and side effects over 6 months to see how well the combo worked in everyday life. The…
Sponsor: The University of Hong Kong • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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New culturally tailored program aims to prevent anxiety in native american youth
Prevention CompletedThis study tested a 6-week program designed to prevent anxiety and depression in American Indian children aged 8-12. The program uses games and role-play to help kids handle stress, and was adapted with input from the tribal community. Researchers worked with 28 children from two…
Sponsor: Montana State University • Aim: Prevention
Last updated Jun 26, 2026 13:30 UTC
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Virtual group therapy shows promise for black Students' mental health
Symptom relief CompletedThis study tested a group teletherapy platform called TheraGroup for Black college students dealing with anxiety and depression. Forty students took part in 12 weeks of cognitive behavioral therapy (CBT) coping skills training delivered online in a group setting. The goal was to …
Sponsor: Dr. Veronica Tetterton • Aim: Symptom relief
Last updated Sep 21, 2026 16:00 UTC
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Can a smartphone program ease anxiety and depression in people with disabilities?
Symptom relief CompletedThis study tests a digital program called Rauha that combines online cognitive behavioral therapy with coaching from trained mental health coaches. It is designed for adults with hearing or mobility disabilities who also experience anxiety or depression. The trial will see if peo…
Sponsor: Toivoa Inc • Aim: Symptom relief
Last updated Aug 23, 2026 00:00 UTC
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AI chatbot aims to ease anxiety and depression in cannabis users
Symptom relief CompletedThis early-phase trial is testing whether a generative AI chatbot called Therabot-CALM is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen participants will use the app for 4 weeks and give feedback through interviews and su…
Phase 1 • Sponsor: Trustees of Dartmouth College • Aim: Symptom relief
Last updated Jul 08, 2026 00:00 UTC
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Gut feeling: probiotics may soothe teen anxiety after surgery
Symptom relief CompletedThis study tested whether giving oral probiotics to adolescents before non-cardiac, non-digestive surgeries could reduce anxiety and depression afterward. 150 teens aged 12-17 were randomly assigned to receive either probiotics or a placebo. Researchers measured anxiety and depre…
Early phase 1 • Sponsor: Henan Provincial People's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Phone app eases pandemic stress in minority communities
Symptom relief CompletedThis study tested a mobile app called EASE to help people manage anxiety and depression during the COVID-19 pandemic. It included 822 adults who identified as Black, Hispanic, or American Indian and had significant anxiety or depression symptoms. The app provided symptom tracking…
Sponsor: University of Houston • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Beauty treatments ease cancer pain and anxiety, study finds
Symptom relief CompletedThis study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…
Sponsor: Centre Hospitalier de Valence • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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New online training aims to ease mental health struggles of doctors and nurses
Symptom relief CompletedThis study tested an online guided self-help program called EMPOWER for medical professionals with mild depression or anxiety. The program teaches problem-solving and acceptance skills through videos and stories. 161 participants were randomly assigned to the program or a control…
Sponsor: Chinese University of Hong Kong • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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Online group therapy helps workers with depression get back on the job
Symptom relief CompletedThis study tested an online group program called Healthy Minds for people on sick leave due to depression, anxiety, or adjustment disorders. 123 participants either joined the 8-week program or received standard care. Researchers tracked their return to work, symptoms, and job fu…
Sponsor: Université du Québec a Montréal • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Laughter may be the best medicine for dialysis patients
Symptom relief CompletedThis study looked at whether online laughter therapy could help people on hemodialysis feel less depressed, anxious, and stressed, and improve their quality of life. Sixty-nine adults who were on dialysis took part. They did laughter therapy sessions online. The results showed th…
Sponsor: Zonguldak Bulent Ecevit University • Aim: Symptom relief
Last updated Jun 27, 2026 12:38 UTC
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Online program eases grief after pregnancy loss, study finds
Symptom relief CompletedThis study tested a 5-week digital counseling program for 54 women who had a pregnancy loss within the past two months. The program focused on emotional support and coping skills. Researchers measured grief and stress levels before, right after, and up to 6 months later to see if…
Sponsor: Gazi University • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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New online therapy eases MS-Related anxiety and depression
Symptom relief CompletedThis study tested an 8-week online program to help people with multiple sclerosis (MS) improve their problem-solving and coping skills. The goal was to see if the program was easy to use and if it helped reduce anxiety and depression. Thirty adults with MS in Lebanon took part. T…
Sponsor: American University of Beirut Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:03 UTC
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Gut feeling: probiotic shows promise for easing anxiety and depression
Symptom relief CompletedThis study tested whether a probiotic called Weizmannia coagulans BC99 can reduce symptoms of anxiety and depression in stressed adults. 79 people took either the probiotic or a placebo for 8 weeks. Researchers measured changes using standard depression and anxiety rating scales.…
Sponsor: Wecare Probiotics Co., Ltd. • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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4-Week exercise program lifts spirits and mobility in elderly
Symptom relief CompletedThis study looked at whether a 4-week program of group exercise, walking, and education could improve depression, anxiety, quality of life, and spinal mobility in elderly nursing home residents. 44 people aged 65 and older took part. The goal was to see if simple, supervised acti…
Sponsor: University of Mostar • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Mindfulness program eases stress in infertile women, study finds
Symptom relief CompletedThis study tested whether an 8-week mindfulness-based stress reduction program could lower stress, anxiety, depression, and cortisol levels in infertile women. 84 women participated, with half taking the program and half serving as a control group. The goal was to see if mindfuln…
Sponsor: Saglik Bilimleri Universitesi • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Ketamine shows promise for Post-Surgery depression in small trial
Symptom relief CompletedThis study tested whether a single dose of ketamine, given during spinal surgery, can reduce depressive symptoms afterward. 110 adults with moderate to severe depression received either ketamine or a saltwater placebo. The goal was to see if ketamine could lower depression scores…
Phase 4 • Sponsor: Benha University • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Phone app could ease distress in breast cancer survivors
Symptom relief CompletedThis study tested whether a mobile app called IntelliCare can reduce depression and anxiety in breast cancer survivors. 313 women who had been diagnosed within the past 5 years and had elevated symptoms used the app or received standard educational materials. The study also looke…
Sponsor: University of Virginia • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Virtual reality headsets could ease ICU trauma for lung transplant patients
Symptom relief CompletedThis study tested whether using virtual reality (VR) exposure therapy could prevent anxiety, depression, and PTSD in people recovering from a lung transplant in the ICU. 62 adults on the lung transplant waiting list participated. They used a VR headset to gradually get used to st…
Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Scientists create new tool to spot hidden emotional behaviors in anxiety and depression
Knowledge-focused CompletedThis study developed and tested a new questionnaire called the Excessive Emotional Behaviors Scale (EEBS) for Chinese adults experiencing anxiety or depression. Researchers interviewed 18 people and surveyed 637 participants to refine the scale, which measures behaviors like avoi…
Sponsor: Xinghua Liu • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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Sleep troubles in kids with CP weigh heavily on parents, study finds
Knowledge-focused CompletedThis study looked at 62 children with cerebral palsy (ages 2-18) and their primary caregivers to understand how the children's sleep problems relate to caregiver burden and mental health. Researchers used questionnaires to measure sleep quality in both children and caregivers, al…
Sponsor: Selim Sezikli • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Study links exercise levels to anxiety and burnout in young doctors
Knowledge-focused CompletedThis study looked at 206 medical residents in France to see if their physical activity levels are linked to anxiety, depression, and burnout. Participants filled out online surveys about their exercise habits and mental health. The goal is to understand whether staying active mig…
Sponsor: University Hospital, Caen • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Neck pain study reveals hidden role of personality and stigma
Knowledge-focused CompletedThis study looked at whether people with long-term neck pain (cervical myofascial pain syndrome) are more likely to have a 'Type D' or distressed personality and feel stigma about their condition. Researchers compared 54 patients with healthy individuals using questionnaires. The…
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Cash for counseling: do incentives get students to therapy?
Knowledge-focused CompletedThis study looked at whether offering cash rewards and sharing screening results could encourage college students in Chennai, India, to use free mental health services. About 340 women students were split into four groups: some just got information, others also learned their scre…
Sponsor: Massachusetts Institute of Technology • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC