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Gut feeling: probiotics may soothe teen anxiety after surgery

NCT ID NCT07640490

Symptom relief Sponsor: Henan Provincial People's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving oral probiotics to adolescents before non-cardiac, non-digestive surgeries could reduce anxiety and depression afterward. 150 teens aged 12-17 were randomly assigned to receive either probiotics or a placebo. Researchers measured anxiety and depression scores over two months after surgery, along with blood markers of inflammation. The goal is to find a simple way to improve mental recovery after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
oral probiotics
What this could lead to
If it works, this could point toward a simple, low-cost way to ease anxiety and depression in teens after surgery.
What could go wrong
This is an early-phase, small trial (150 participants) with no results yet. Probiotics may not affect mood, and individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

150 people

The number who actually took part.

Started

Aug 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 17 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 8 years ≤ age ≤17 years; * Patients who plan to undergo elective surgery under general anesthesia, and the operation time is 1-2 hours; * ASA grade I-II * The body mass index falls within the normal range, which is 18.5 - 23.9 kg/m2. Exclusion Criteria: * The patient has psychological disorders, including but not limited to bipolar affective disorder. * Eating disorder * No informed consent form * Due to certain serious diseases, one needs to take medication for a long period of time. * Personality disorder * Has undergone or needs to undergo gastrointestinal surgery * Have taken antibiotics or probiotics within the past 8 weeks * Pure vegetarian diet

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Conditions

The condition(s) this trial relates to.

mixed anxiety and depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety depression

Contacts and locations

Locations

  • Henan Provincial People's Hospital

    Zhengzhou, Henan, 450000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.