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Ketamine shows promise for Post-Surgery depression in small trial

NCT ID NCT06060210

Symptom relief Sponsor: Benha University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a single dose of ketamine, given during spinal surgery, can reduce depressive symptoms afterward. 110 adults with moderate to severe depression received either ketamine or a saltwater placebo. The goal was to see if ketamine could lower depression scores by more than half within a week. The trial is complete, and results may show whether ketamine is a safe and effective option for managing post-surgery mood.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketamine
What this could lead to
If it works, this could point toward a simple way to reduce depression after surgery, improving recovery and quality of life.
What could go wrong
This is a small, completed Phase 4 trial. The results may not apply to all surgeries or depression types, and ketamine can cause side effects like high blood pressure or hallucinations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

110 people

The number who actually took part.

Started

Oct 2023

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 44 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients of both sex * with an age range from 20 to 44 years old * having moderate to severe depressive symptoms * an expected hospital stay of no less than 7 days Exclusion Criteria: * history of epilepsy * major depressive disorder patients * drug abuse * history of allergy to the research drug * heart rate \> 120 beats per minute * systolic blood pressure \> 180 mmHg * heart failure * renal or liver dysfunction * patients who cannot cooperate to complete psychiatric assessments * pregnant or breast-feeding women * patients who refuse to sign informed consent.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression mixed anxiety and depressive disorder pseudotumor cerebri

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression, anxiety

Contacts and locations

Locations

  • Banha faculity of medicine

    Banhā, Elqalyoubea, 13511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.