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Gut feeling: probiotic shows promise for easing anxiety and depression

NCT ID NCT07353320

Symptom relief Sponsor: Wecare Probiotics Co., Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a probiotic called Weizmannia coagulans BC99 can reduce symptoms of anxiety and depression in stressed adults. 79 people took either the probiotic or a placebo for 8 weeks. Researchers measured changes using standard depression and anxiety rating scales. The goal was to see if improving gut bacteria could boost mental health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Weizmannia coagulans BC99 (a probiotic)
What this could lead to
If it works, this could point toward a simple, natural supplement to help manage mild anxiety and depression.
What could go wrong
This is a small, early-stage trial with only 79 people. The effect may be small or no better than placebo, and results may not apply to everyone with anxiety or depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

79 people

The number who actually took part.

Started

Apr 2024

Finished

Apr 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults aged 18-65 years. 2. Individuals experiencing scientific research, employment-related, or occupational stress, including graduate students or community-dwelling adults with job-related pressure. 3. A Hamilton Depression Rating Scale (HAMD-17) score ≥ 8 and/or a Hamilton 4) Anxiety Rating Scale (HAMA-14) score ≥ 7 at screening. 5)Ability and willingness to voluntarily participate in the study and to provide written informed consent prior to enrollment. Exclusion Criteria: 1. A confirmed previous diagnosis of other psychiatric disorders, including intellectual disability, bipolar disorder, treatment-resistant depression, or suicidal ideation. 2. Pregnant or breastfeeding women. 3. Individuals with known food or drug allergies, or those with alcohol abuse or psychotropic substance abuse. 4. Use of antibiotics or probiotics known to affect gut microbiota for more than one week within one month prior to enrollment. 5. Participants who withdrew from the study, discontinued intervention, or were unable to complete the study for any reason.

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Conditions

The condition(s) this trial relates to.

anxiety depressive disorder mixed anxiety and depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety depression

Contacts and locations

Locations

  • Henan University of Science and Technolog

    Luoyang, Henan, 462000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.