Methamphetamine dependence

This trial investigates whether a single dose of psilocybin, given during a supervised session and paired with brief cognitive behavioral therapy, can help adults with moderate to severe methamphetamine use disorder reduce or stop their use. Participants receive one of two dose l…

Researchers at UT Southwestern Medical Center are testing whether tirzepatide, a drug approved for diabetes and weight loss, can help people with moderate to severe methamphetamine use disorder reduce or stop using the drug. The trial enrolls 228 adults aged 18 to 65 who are over…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can reduce drug cravings in people with methamphetamine use disorder. The stimulation targets the nucleus accumbens, a brain region involved in reward and a…

This pilot trial tests whether a personalized brain stimulation technique can help people with methamphetamine use disorder. The approach uses closed-loop theta-burst stimulation, which delivers magnetic pulses to a specific brain region in real time, triggered by the person's ow…

This trial explores whether a single dose of psilocybin, combined with motivational support therapy, can help people with HIV who have moderate-to-severe methamphetamine use disorder reduce or stop their meth use. Participants will be randomly assigned to receive either a higher …

This phase 2 trial will test whether semaglutide, the drug in Ozempic, can help people with methamphetamine use disorder cut down their use. Forty adults who use methamphetamine at least 14 days per month will receive weekly injections for 12 weeks. The study will check if the tr…

This pilot study will test a clinic that treats both heart failure and methamphetamine use disorder at the same time. Fifty adults with heart failure and active meth use will receive counseling, incentives for staying clean, and optional addiction medications, plus standard heart…

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This clinical trial is testing a medical device that has not yet been approved by the U.S. FDA. Because the trial details are withheld, the exact purpose, participants, and approach are not publicly known. The study is likely gathering early information on the device's safety and…

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find n…

This study will test a new visual scale designed to help people who use methamphetamine estimate how much they use each day. Researchers will compare the scale's results with hair samples and other methods to see if it is accurate and easy to use. About 100 people aged 20-40 who …

This study will test if simple, bedside heart tests (ultrasound, EKG, and blood tests) can accurately detect heart problems in pregnant women who regularly use methamphetamine. Researchers will compare these quick tests to a full heart ultrasound. The goal is to find a faster, ea…