Metastatic carcinoma in the bone

This phase 3 trial tests whether giving radiation therapy early — before symptoms appear — can reduce the risk of bone complications (like fractures or spinal cord pressure) in people with solid tumors that have spread to the bone. Participants have bone lesions that are consider…

This trial investigates whether surgically removing the primary breast tumor, followed by standard systemic therapy, improves survival compared to systemic therapy alone in women with stage IV breast cancer that has spread only to a single bone site. The study enrolls women aged …

This trial tests a highly targeted radiation technique called stereotactic body radiotherapy (SBRT) against standard radiotherapy for people whose cancer has spread to the spine but has not yet compressed the spinal cord. The goal is to see if SBRT can better prevent tumor growth…

This study tests whether giving radiation early to bone spots where cancer has spread can prevent complications like fractures or spinal cord pressure. About 90 adults with solid cancers that have spread to up to five bones will either get standard care or standard care plus radi…

This study looks at whether starting denosumab early, along with a standard immunotherapy, can prevent bone problems like fractures or spinal cord compression in people with liver cancer that has spread to the bones. About 50 adults with liver cancer and bone metastases will be r…

This study tests whether giving a combination of intravenous iron, erythropoietin (EPO), and tranexamic acid before bone tumor surgery can improve hemoglobin levels and reduce the need for blood transfusions compared to usual care. The trial enrolls 160 adults with anemia or iron…

This clinical trial tests a new drug called BPR-6023021, which is a radioactive compound designed to target bone. It is for people with advanced solid tumors that have spread to the bone and who have no other standard treatment options. The study will enroll 195 participants to e…

This study tests an artificial intelligence (AI) model designed to detect bone lesions on whole-body PET/CT scans. Researchers will enroll 180 adults with suspicious bone findings to see how well the AI can tell benign from malignant lesions, and predict tumor type, genetics, and…

This study will test whether a special CT scan (dual-energy CT) can be as good as MRI for mapping tumors and healthy organs before radiation therapy. Researchers will enroll 80 people with brain, bone, head/neck, or lung cancer. If DECT works well, it could save time and money co…

This trial is testing whether a single, higher dose of radiation (8 Gy) can relieve pain from bone metastases as effectively as a standard course of five smaller doses (20 Gy total). The study includes adults with cancer that has spread to the bones and who have significant pain.…

This trial tests an experimental drug called VC004 for people with moderate-to-severe pain caused by cancer that has spread to the bones. About 26 adults will receive either a low or high dose of VC004 or a placebo capsule, and researchers will track changes in daily pain scores …

This study tests whether a special glass-based bone cement, used with ultrasound during surgery, can safely stabilize bones and reduce pain in people with advanced cancer that has spread to the pelvis. Eight adults aged 18 to 80 with painful pelvic bone tumors will receive the tr…

This trial tests whether monitoring sacral reflexes during surgery can predict nerve function afterward. Patients undergoing sacrectomy for pelvic bone cancer or spinal procedures will have their reflexes tracked in real time. The goal is to help surgeons make decisions and prepa…

This study is developing a way to predict who might develop a serious jaw bone condition called medication-related osteonecrosis of the jaw (MRONJ) after dental procedures. Researchers are following adults who have taken bone-strengthening drugs like bisphosphonates or denosumab …