Mature T-cell and NK-cell non-Hodgkin lymphoma

This Phase 1 trial tests a new type of cell therapy for people with relapsed or refractory CD30-positive lymphomas, including Hodgkin lymphoma and certain non-Hodgkin lymphomas. The treatment uses a patient's own immune cells that are genetically engineered to recognize and attac…

This trial is testing an experimental drug called FG-M131 in people with a type of blood cancer called peripheral T-cell lymphoma that has come back or not responded to prior treatment. FG-M131 is designed to target and destroy cancerous T cells that carry a marker called TRBC1, …

This phase II trial tests whether adding stapokibart to standard immune checkpoint inhibitors can help people with relapsed or refractory lymphoma, a type of blood cancer that has not responded to or has returned after prior treatment. About 20 adults who have already failed immu…

This phase 2 trial is testing whether a combination of five drugs—chidamide, azacitidine, prednisone, cyclophosphamide, and thalidomide—can help people with peripheral T-cell lymphoma (PTCL) who are unable to tolerate standard chemotherapy. The study will enroll 58 adults with PT…

This trial is testing whether adding an experimental targeted drug, SHR2554, to standard chemotherapy (liposomal mitoxantrone) can improve outcomes for people with peripheral T-cell lymphoma (PTCL) who have not yet been treated. The study involves about 44 adults with certain PTC…

This trial tests whether adding targeted drugs (azacitidine or decitabine plus selinexor) to standard chemotherapy improves outcomes for people newly diagnosed with peripheral T-cell lymphoma. Participants are assigned treatment based on their tumor's genetic profile. The study f…

This early-phase trial tests two different drug combinations for people with T-cell lymphoma that has come back or not responded to prior treatment. One group receives belinostat plus azacitidine; the other receives belinostat plus pralatrexate. The goal is to find the safest dos…

This study tests whether adding the experimental drug BEBT-908 to standard CHOP chemotherapy works better than CHOP alone for people with previously untreated peripheral T-cell lymphoma (PTCL). The trial first explores different dosing schedules to find the best way to combine th…

This study tests a new drug called TR115 in about 180 adults with a rare blood cancer (T/NK-cell lymphoma) that has come back or not responded to prior treatments. Participants will receive either TR115 or one of several standard drugs. The main goal is to see if TR115 can slow c…

This study tests two drugs, adebrelimab and SHR2554, together in about 40 adults whose T-cell lymphoma has come back or not responded to treatment. The goal is to find a safe dose and see if the combination can shrink tumors. Participants must have certain types of T-cell lymphom…

This phase 2 trial tests a new chemotherapy combination called CAOP for elderly patients (65+) with untreated peripheral T-cell lymphoma, a rare blood cancer. The standard treatment often causes heart damage, but this regimen replaces the heart-toxic drug with a safer one. The st…

This study tests a vaccine called KSD-101 in 80 people with blood cancers linked to the Epstein-Barr virus (EBV). The vaccine uses a patient's own immune cells to target EBV and cancer. Researchers want to see if it can shrink tumors or keep the disease from coming back.

This study tests a new approach for people with a type of lymphoma (PTCL) that did not respond to initial chemotherapy. Doctors will use genetic testing of the tumor to choose a personalized combination of drugs, including an experimental drug called zeprumetostat. The goal is to…

This phase 2 trial tests a combination of three drugs—golidocitinib, pegaspargase, and an immunotherapy—as a first treatment for advanced NK T-cell lymphoma, a rare and aggressive cancer. The study will enroll 40 people who have not had prior therapy. The goal is to see if this c…

This study tests a new drug called BR101801 in 44 people with a rare type of blood cancer (peripheral T-cell lymphoma) that has returned or not responded to standard treatments. The goal is to see if the drug can shrink tumors and how safe it is. Participants will receive the dru…

This study tests a drug called SHR2554 as a maintenance therapy for people with peripheral T-cell lymphoma who have responded to initial treatment. The goal is to see if taking this pill can help keep the cancer from progressing for longer. About 30 adults who have achieved compl…

This study tests a new drug called zeprumetostat, combined with either golidocitinib or chidamide, in 60 adults with relapsed or refractory mature T-cell and NK-cell lymphomas. The goal is to find safe doses and see if the combination shrinks tumors. It is an early-phase trial, s…

This study tests a combination of two drugs, mitoxantrone hydrochloride liposome and enlonstobart, in people with peripheral T-cell lymphoma that has come back or not responded to treatment. The goal is to find the safest and most effective dose and see how well the combo works. …

This phase 2 trial tests a combination of the drug golidocitinib plus chemotherapy (gemcitabine and oxaliplatin) in 31 adults with relapsed or refractory peripheral T-cell lymphoma, a rare and aggressive blood cancer. The goal is to see if the combo safely shrinks tumors and dela…

This study tests a combination of three chemotherapy drugs (thiotepa, cyclophosphamide, and busulfan) given before a stem cell transplant for people with NK/T-cell lymphoma. The goal is to see if this approach helps keep the cancer from coming back. About 37 adults aged 18-70 who…

This study tests whether a combination of two drugs, selinexor and azacitidine, can help prevent NK/T-cell lymphoma from returning after a stem cell transplant. About 39 adults aged 18-70 who have already received a transplant will take these drugs as maintenance therapy. The goa…

This study tests whether combining tazemetostat with either linperlisib or golidocitinib can safely shrink tumors in people with relapsed or refractory peripheral T-cell lymphoma. About 48 adults who have already tried at least one other treatment will receive the drugs by mouth.…

This study will follow 1000 people diagnosed with peripheral T-cell lymphoma (PTCL) to see how different genetic subtypes affect disease progression and treatment response. Researchers will collect data from multiple hospitals and use genetic testing to classify patients. The goa…