Malignant glioma
MONDO:0100342A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma.
Also known as: glioma, neuroglial tumor, neuroglial tumour, glial cell tumour, glioma, malignant, high grade glioma, high-grade glioma, malignant glial neoplasm
3637 clinical trials for this condition and its sub-types, 250 tagged with Malignant glioma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Malignant glioma
-
High grade astrocytic tumor 8 trials · 668 incl. sub-types
3 sub-types
- Glioblastoma 634 trials · 647 incl. sub-types Sub-types →
- Anaplastic astrocytoma 53 trials · 99 incl. sub-types Sub-types →
- Gliomatosis cerebri 1 trial
-
Brain glioma 29 trials · 210 incl. sub-types
8 sub-types
- Brain stem glioma 11 trials · 101 incl. sub-types Sub-types →
- Brain glioblastoma 24 trials · 87 incl. sub-types Sub-types →
- Ependymal tumor of brain 3 trials · 5 incl. sub-types Sub-types →
- Chordoid glioma of the third ventricle 1 trial
- Diencephalic astrocytomas 0 trials · 1 incl. sub-types Sub-types →
- Gliomatosis cerebri 1 trial
- Brain oligodendroglioma 0 trials Sub-types →
- Childhood cerebral astrocytoma 0 trials Sub-types →
-
Grade III glioma 44 trials · 86 incl. sub-types
3 sub-types
- Anaplastic oligodendroglioma 22 trials · 35 incl. sub-types Sub-types →
- Anaplastic ependymoma 7 trials · 12 incl. sub-types Sub-types →
- Anaplastic oligoastrocytoma 12 trials
-
Oligodendroglial tumor 2 trials · 72 incl. sub-types
2 sub-types
- Oligodendroglioma 61 trials Sub-types →
- Anaplastic oligodendroglioma 22 trials · 35 incl. sub-types Sub-types →
-
Malignant peripheral nerve sheath tumor 36 trials · 38 incl. sub-types
7 sub-types
- Epithelioid malignant peripheral nerve sheath tumor 2 trials
- Childhood malignant schwannoma 1 trial
- Malignant melanocytic neoplasm of the peripheral nerve sheath 1 trial Sub-types →
- Malignant triton tumor 1 trial
- Adult malignant schwannoma 0 trials
- Malignant cardiac peripheral nerve sheath neoplasm 0 trials
- Malignant glandular tumor of peripheral nerve sheath 0 trials
-
Pediatric high-grade glioma 14 trials · 16 incl. sub-types
1 sub-type
-
Spinal cord glioma 3 trials
4 sub-types
- Adult spinal cord glioblastoma 0 trials
- Ependymal tumor of spinal cord 0 trials Sub-types →
- Spinal cord astrocytoma 0 trials
- Spinal cord oligodendroglioma 0 trials
-
Granular cell cancer 1 trial · 2 incl. sub-types
4 sub-types
- Malignant cutaneous granular cell skin tumor 1 trial
- Granular cell carcinoma 0 trials
- Granular cell leiomyosarcoma 0 trials
- Malignant gastric granular cell tumor 0 trials
-
Malignant perineurioma 1 trial
-
Isolated melanotic schwannoma 0 trials
-
Neurofibroma of gallbladder 0 trials
-
Neurofibroma of the heart 0 trials
Most studied deeper sub-types
-
New combo therapy shows promise for kids with tough cancers
Disease control Stopped earlyThis study tested a combination of an immunotherapy drug (nivolumab) and low-dose chemotherapy in children and teenagers whose solid tumors had not responded to standard treatments. The goal was to see if the combination was safe and could help control the cancer. The trial was s…
Phase 1/2 • Sponsor: Centre Oscar Lambret • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
-
Sound waves and drug team up against brain tumors
Disease control Stopped earlyThis early-phase trial tested a combination of a drug called aminolevulinic acid (ALA) and focused ultrasound to treat recurrent high-grade glioma, an aggressive brain cancer. The study aimed to see if this sonodynamic therapy could safely damage tumor cells. Only 10 participants…
Early phase 1 • Sponsor: Nader Sanai • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
-
New way to deliver chemo directly to brain tumors tested in small study
Disease control Stopped earlyThis early-phase trial tested a single dose of the cancer drug temsirolimus, given directly into the brain's blood supply, for people with recurrent high-grade glioma (a fast-growing brain tumor). Only 5 participants were enrolled, and the study was terminated early. The main goa…
Early phase 1 • Sponsor: Nader Sanai • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
-
Experimental immune therapy for childhood brain cancer shows early safety signals
Disease control Stopped earlyThis early-phase study tested whether a personalized vaccine made from a child's own tumor could train their immune system to fight high-grade gliomas. The treatment involved giving back activated immune cells (T-cells) and dendritic cell vaccines after chemotherapy. Only 5 child…
Phase 1 • Sponsor: University of Florida • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
-
Experimental combo therapy for brain cancer shows promise in early trial
Disease control Stopped earlyThis study tested a special type of radiation (pulse reduced dose rate) combined with the drug bevacizumab in 49 people with recurrent high-grade gliomas (brain tumors). The goal was to see if this combination could help patients live longer. Participants received radiation over …
Phase 2 • Sponsor: University of Wisconsin, Madison • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
-
Experimental virus gets a second shot at brain tumors
Disease control Stopped earlyThis study tested the safety of giving a second dose of an experimental virus (C134) directly into the brain tumor of patients whose malignant glioma had returned. Only one patient was enrolled before the study was stopped. The goal was to see if repeat dosing was safe and tolera…
Phase 1 • Sponsor: University of Alabama at Birmingham • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
-
Experimental Pre-Surgery treatment for brain cancer shows early hurdles
Disease control Stopped earlyThis study looked at whether giving chemotherapy and radiation before surgery could help control glioblastoma, a fast-growing brain tumor. Only 2 people enrolled before the study was stopped. The goal was to see if this approach was safe and could delay tumor regrowth.
Phase 2 • Sponsor: Geisinger Clinic • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
-
New drug cocktail shows promise for tough childhood cancers
Disease control Stopped earlyThis early-phase trial tested a combination of three drugs—ribociclib, topotecan, and temozolomide—in children with relapsed or refractory neuroblastoma and other solid tumors. The goal was to find a safe dose and see if the combination could shrink tumors. Only 12 children took …
Phase 1 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
-
Experimental cancer pill targets Hard-to-Treat gene mutations
Disease control Stopped earlyThis early study tested an experimental oral drug called IK-595 in people with advanced solid tumors that have specific RAS or RAF gene mutations. The goal was to check safety, dosing, and early signs of tumor shrinkage. The study was terminated before completion, so full results…
Phase 1 • Sponsor: Ikena Oncology • Aim: Disease control
Last updated Jun 26, 2026 19:17 UTC
-
Brain tumor drug penetration study halted early
Knowledge-focused Stopped earlyThis early-phase trial aimed to measure how much of the drug infigratinib reaches brain tumor tissue in people with recurrent high-grade glioma (a type of brain cancer). Only 7 participants were enrolled before the study was terminated. The main goal was to check drug levels in t…
Early phase 1 • Sponsor: Nader Sanai • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC
-
Scientists examine stored tumor samples to uncover DNA clues in Kids' brain cancers
Knowledge-focused Stopped earlyThis study looked at stored tumor samples from 139 children with brain and central nervous system tumors. Researchers wanted to find DNA changes and biomarkers that could help understand these cancers better. The study was terminated early, so results may be limited.
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC