Malignant glioma

Researchers are testing an experimental therapy called SRN-101 in adults with recurrent high-grade glioma, an aggressive brain cancer that has returned after standard treatment. Participants receive SRN-101 directly into the tumor before planned surgery to remove it. The trial's …

Researchers are testing whether GammaTile, a collagen tile embedded with radioactive cesium-131 seeds, can be safely placed in the brain after surgery for malignant glioma. The trial enrolls elderly or frail patients with newly diagnosed or recurrent tumors. The main goals are to…

This early-phase trial tests an experimental drug called NST-628 in adults with recurrent grade 4 glioma, an aggressive brain cancer. The study aims to see how well the drug enters the tumor and affects cancer-related proteins, as well as its safety. Participants take the drug be…

This study tests a drug called ADI-PEG 20, which breaks down an amino acid that some brain tumors need to grow. It is given alongside standard radiation and chemotherapy to children, adolescents, and young adults with newly diagnosed high-grade glioma. The goal is to see if this …

This early-phase study tests a new treatment for children and young adults with aggressive brain tumors called high-grade glioma and DIPG. The therapy uses the patient's own immune cells, modified in a lab to better recognize and attack tumor cells. The main goals are to see if t…

This study is for adolescents and young adults (ages 12-39) newly diagnosed with aggressive brain tumors called high-grade glioma or DIPG. The goal is to see if a combination of two immunotherapy drugs (relatlimab and nivolumab, sold as Opdualag) is safe and tolerable when given …

This phase 1 trial tests whether FPS-ZM1, a drug that blocks an inflammation pathway, can safely control brain swelling that often occurs after surgery for glioblastoma, a type of brain cancer. Researchers will give FPS-ZM1 with or without the steroid dexamethasone to about 24 ad…

This trial is testing whether giving tarlatamab before and after surgery is safe and feasible for people with recurrent high-grade glioma, an aggressive brain cancer. Participants receive tarlatamab infusions before their tumor is removed, then continue treatment after surgery. T…

This trial tests an oral drug called JBI-778 in people with brain metastases, leptomeningeal disease, or recurrent high-grade glioma. The drug is designed to block a protein that may help tumors grow. The study aims to find the safest dose and see if the drug can shrink tumors or…

This study tests a drug called tovorafenib in children and young adults (ages 1 to 39) newly diagnosed with aggressive brain tumors (high-grade glioma or DIPG) that have specific genetic changes. The goal is to see if the drug can help them live longer. About 79 participants will…

This study tests a virus called G207 combined with a small dose of radiation in children whose high-grade glioma has come back or is growing. The goal is to see if the treatment is safe and helps control the tumor. About 38 children will take part.

This pilot trial is testing a medical device called GlioHook, which is implanted in the brain after surgery to remove a high-grade glioma. The implant is designed to trap any remaining tumor cells and make follow-up radiotherapy more effective. The study includes about 15 adults …

This phase 1 trial tests whether disulfiram, a drug long used for alcohol dependence, can reduce immune suppression caused by high-grade gliomas. Participants take disulfiram for 3 to 14 days before their scheduled tumor-removal surgery. The goal is to see if the drug can dampen …

This phase 2 trial tests whether adding nimotuzumab—an antibody that blocks a protein called EGFR—to the standard Stupp regimen (temozolomide plus radiotherapy) can improve outcomes for adults with glioblastoma that was not fully removed by surgery. Participants must have EGFR-po…

This early-stage trial tests a new treatment for recurrent high-grade glioma, an aggressive brain cancer. The approach uses a specially designed virus injected directly into the tumor to kill cancer cells and boost the immune system, combined with a PD-1 inhibitor drug that helps…

This trial compares three approaches to manage brain swelling after surgery for high-grade glioma: standard steroids (dexamethasone), no routine steroids, and a study drug called azeliragon that targets swelling through a different mechanism. The goal is to see if these alternati…

This phase 2 trial tests a single dose of FG001, a fluorescent dye, in 76 adults with newly diagnosed high-grade glioma. The dye is given before surgery and glows under a special light, helping surgeons tell tumor from healthy tissue during removal. The study checks how well the …

This study tests two immunotherapy drugs, fianlimab and cemiplimab, in children and young adults with recurrent high-grade glioma or ependymoma. The goal is to see if the combination is safe and can shrink tumors or slow their growth. Participants will receive the drugs before an…

This phase 2 trial tests the drug mirdametinib, alone or with radiation, in people with NF1-related high-grade gliomas (aggressive brain tumors). It includes three groups: those with recurrent sporadic glioblastoma, newly diagnosed NF1-associated glioblastoma, and other NF1-relat…

This early-stage trial is testing a new treatment called CHT101 for adults with aggressive brain tumors that have returned or worsened despite standard care. CHT101 is a type of immune cell therapy (CAR T-cells) designed to recognize and attack tumor cells carrying a protein call…

This early-phase trial tests a new treatment for people whose malignant glioma (a type of brain cancer) has come back. The therapy uses the patient's own immune cells, modified to recognize and attack the cancer while also blocking a tumor defense mechanism. The study will enroll…

This early-stage trial tests whether using a special MRI-guided radiation machine (MR-Linac) can safely deliver higher, more targeted radiation doses to aggressive brain tumors (high-grade glioma). Twenty newly diagnosed patients will receive radiation twice a week for three week…

This early-stage study tests a new drug called FZ-AD005 in 40 people with aggressive brain tumors (high-grade glioma) that have come back or not responded to treatment. The drug is designed to target and kill cancer cells while sparing healthy ones. The main goals are to find the…

This early-stage study tests an experimental drug called gallium maltolate in 15 children whose high-grade glioma or atypical teratoid rhabdoid tumor has returned or not responded to treatment. The main goals are to find safe doses and understand side effects. Everyone receives t…

This first-in-human study will test a new radioactive imaging agent called MeFAMP to see if it can safely and accurately detect brain tumors using PET scans. The study includes 28 people: healthy volunteers and patients with recurrent high-grade glioma or brain metastases from ot…

This study explores whether analyzing tumor DNA in cerebrospinal fluid can help doctors make better treatment decisions for people with malignant brain tumors or brain metastases from lung or breast cancer. Participants undergo a standard spinal tap or fluid collection, and the f…

This study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers w…

Researchers at Odense University Hospital are testing whether monitoring brain signals during tumor surgery can help preserve functions like movement, speech, and vision. The project includes a randomized trial comparing surgery with and without motor signal monitoring, plus obse…

This study tests whether combining PET scans with two investigational tracers, [18F]FET and [18F]FMISO, along with MRI, can help doctors place catheters more accurately for delivering therapy to recurrent brain tumors (malignant gliomas). About 20 adults already enrolled in a mai…

This study will test whether a special brain scan called magnetoencephalography (MEG) can detect electrical differences within gliomas, the most common malignant brain tumors in adults. Researchers will scan 60 newly diagnosed patients before surgery to see if MEG can identify mo…

This study tests whether special MRI scans can spot where brain tumors have spread into nearby healthy tissue, which standard scans miss. About 20 adults with suspected high-grade glioma will get extra scans before surgery. The results will be compared to tissue samples to see if…

This study looks at whether a special PET scan (18F-AGX) can detect early changes in brain tumor activity in adults with slow-growing IDH-mutant gliomas who are taking the drug Vorasidenib. Ten participants will get the drug daily for about a year and have multiple PET and MRI sc…

This study tests whether physical therapy, alone or with brain stimulation, can help rewire the brain before surgery for high-grade glioma near the motor area. About 63 adults with preserved movement will be randomly assigned to standard care, therapy, or therapy plus stimulation…

This study tests giving chemotherapy before radiation for people with high-grade gliomas, a type of aggressive brain tumor. The goal is to see if this approach works well and makes MRI scans easier to read, since radiation can change how the brain looks. About 70 adults aged 18-8…

This study tests a special microscope accessory called GLOW400 that helps surgeons see glowing brain tumors during surgery. About 37 adults with suspected high-grade gliomas will take part. Surgeons will rate how well the device shows tumor fluorescence and image quality. The goa…

This study tests how well the MyVeo surgical headset shows surgical details during routine brain, spine, ear-nose-throat, or reconstructive surgeries. Surgeons will rate image quality, comfort, and safety while using the device. About 32 patients will take part, and no extra proc…

This study tests a special camera attached to a surgical microscope to see if it can better detect glioma tumor cells during brain surgery. Researchers will observe 80 adults with suspected high-grade gliomas. The goal is to improve how surgeons see tumor tissue, not to test a ne…