Lynch syndrome
MONDO:0005835An autosomal dominant hereditary neoplastic syndrome characterized by the development of colorectal carcinoma and a high risk of developing endometrial carcinoma, gastric carcinoma, ovarian carcinoma, renal pelvis carcinoma, and small intestinal carcinoma. Patients often develop colorectal carcinomas at an early age (mean, 45 years). In the majority of the cases the lesions arise from the proximal colon. At the molecular level, high-frequency microsatellite instability is present.
Also known as: Hereditary colorectal endometrial cancer syndrome, Hereditary non-polyposis colon cancer (hMSH2, hMLH1, hPMS1, hPMS2), Hereditary nonpolyposis colon cancer (hMSH2, hMLH1, hPMS1, hPMS2), Lynch syndrome, familial non-polyposis colon cancer (hMSH2, hMLH1, hPMS1, hPMS2), hereditary defective mismatch repair syndrome
2977 clinical trials for this condition and its sub-types, 81 tagged with Lynch syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Lynch syndrome
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Lynch syndrome 1 5 trials
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Lynch syndrome 2 3 trials
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Lynch syndrome 4 0 trials
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Lynch syndrome 5 0 trials
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Lynch syndrome 8 0 trials
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New hope for advanced colon cancer: immune drug shrinks tumors in genetic subtype
Disease control CompletedThis study tested whether the immunotherapy drug nivolumab, alone or with other drugs, can shrink tumors in people with colon cancer that has returned or spread. It included 385 participants whose tumors had a specific genetic feature called MSI-H or were non-MSI-H. The goal was …
Phase 2 • Sponsor: Bristol-Myers Squibb • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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A watchful eye: could alternating scans outsmart pancreatic cancer?
Diagnosis CompletedThis study follows people with a significantly elevated risk of pancreatic cancer—due to inherited gene mutations or strong family history—who choose to undergo early detection testing. Participants receive endoscopic ultrasound (EUS) and MRI scans on an alternating schedule ever…
Sponsor: White Plains Hospital • Aim: Diagnosis
Last updated Aug 27, 2026 00:00 UTC
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AI boosts colonoscopy accuracy for lynch syndrome patients?
Diagnosis CompletedThis study tested whether using artificial intelligence (AI) during colonoscopy helps find more polyps in people with Lynch syndrome, a genetic condition that raises colon cancer risk. One hundred participants each had two colonoscopies back-to-back, with the second using either …
Sponsor: Sheba Medical Center • Aim: Diagnosis
Last updated Jun 27, 2026 12:10 UTC
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Lynch syndrome patients share colonoscopy struggles in new survey
Knowledge-focused CompletedThis study surveyed 231 adults with Lynch syndrome, an inherited condition that raises bowel cancer risk. Researchers wanted to find out how many people follow the UK recommendation of a colonoscopy every two years, and what makes it harder or easier to keep up with these check-u…
Sponsor: Imperial College London • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:03 UTC
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Teens and parents share feelings on genetic risk results
Knowledge-focused CompletedThis study explored how teenagers and their parents react emotionally and mentally when they learn about genetic risks for conditions like hereditary breast cancer, Lynch syndrome, or high cholesterol. Researchers surveyed 162 participants using questionnaires and interviews to m…
Early phase 1 • Sponsor: Geisinger Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Can an online program help african american women learn their genetic cancer risk?
Knowledge-focused CompletedThis completed study tested whether an online self-guided program could effectively return genetic test results for hereditary breast and ovarian cancer to African American women. Over 900 women from the Black Women's Health Study were offered their results online or by printed m…
Sponsor: Boston University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Large study looks at how a 25-Gene cancer test affects patients and families
Knowledge-focused CompletedThis study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …
Sponsor: University of Southern California • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Universal DNA screening in endometrial cancer reveals hidden genetic risks
Knowledge-focused CompletedThis study tested over 1,000 women with endometrial cancer for DNA repair problems that can be inherited (Lynch syndrome). By analyzing tumor DNA, researchers aimed to personalize cancer treatment and identify family members who might also be at risk. The goal was to improve care…
Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC