Lumbar spinal stenosis

This trial is testing whether ProteiOS®, a growth factor derived from donor bone, can help bones in the lower spine fuse together as effectively as the standard approach using a patient's own bone. Adults with degenerative spine conditions needing lumbar fusion surgery will be ra…

This trial compares two surgical approaches for people who develop spinal stenosis near a previous lumbar fusion. One group receives a smaller surgery (microdecompression alone), while the other gets the standard larger surgery (decompression plus extending the fusion). The study…

This study looks at whether CT scans taken during lumbar spine surgery can detect spinal instability more reliably than standard X-rays taken before surgery. Researchers will review imaging and medical records from 100 adults undergoing surgery for degenerative spine conditions. …

Many people with lumbar spinal stenosis get pain relief from decompression surgery but still do not walk more afterward. This pilot trial tests whether a behavioral program can change that. Researchers randomly assign 75 patients aged 40 to 85 to either the program, which pairs m…

This trial tests whether an 8-week virtual reality-based cognitive behavioral therapy (VR-CBT) program, done at home before elective spine surgery, can improve recovery and quality of life. Adults scheduled for spinal fusion will be randomly assigned to receive VR-CBT plus usual …

This study compares two surgical options for people who develop spinal stenosis (narrowing of the spine) above a previous fusion site. One group gets decompression alone (removing tissue pressing on nerves), while the other gets decompression plus extended fusion (adding screws a…

This study tests two ways to guide a steroid injection for people with lumbar spinal stenosis, a condition that causes back and leg pain when walking or standing. One method uses X-ray (fluoroscopy) alone, the other adds ultrasound before the X-ray (hybrid). The goal is to see wh…

This study will compare two types of nerve blocks—lumbar paravertebral block and lumbar erector spinae plane block—for pain control after lumbar spine surgery in people aged 65 and older. The goal is to see which block reduces the need for opioid painkillers in the first 48 hours…

This study compares two common back surgeries for people with lumbar spinal stenosis (a narrowing of the spine that presses on nerves). One surgery only removes the pressing bone and tissue, while the other also adds metal screws and rods to stabilize the spine. Researchers will …

This study compares two types of keyhole spine surgery for middle-aged and older adults with lumbar spinal stenosis, a condition that causes leg pain and trouble walking. One surgery just removes the tissue pressing on nerves, while the other also fuses the bones together. The go…

This study tests whether a continuous nerve block placed by the surgeon during back surgery can reduce pain and the need for opioids afterward. One hundred adults having lumbar spine surgery will be randomly assigned to receive either the nerve block with a numbing medicine or a …

This study tests whether a modified mini-open spine surgery (mMO-TLIF) works as well as or better than traditional open surgery for people with lumbar spinal stenosis and instability. About 224 adults aged 18 to 80 with persistent leg pain or walking problems will be randomly ass…

This trial tests whether an extra consultation using a predictive tool, called Dialogue Support, helps adults scheduled for lumbar spine surgery understand their likely outcomes. The tool estimates how a patient may fare one year after surgery and presents that information visual…

This study looks at how different types of obesity—central (belly fat) versus peripheral (fat elsewhere)—affect blood loss and complications during major lower back surgery. Researchers will measure pressure inside the abdomen and blood loss in 90 adults having lumbar spine surge…

This study will observe how different spinal problems—like scoliosis, stenosis, or herniated discs—change the way people walk and use their back muscles. Researchers will compare 120 older adults (age 60+) with these conditions to healthy volunteers using motion cameras and muscl…