Lumbar disk degenerative disorder

This trial compares two FDA-approved cages used in lower back fusion surgery to see if one helps the bones fuse together better than the other. Adults undergoing a 1- or 2-level lumbar fusion for degenerative disc disease will be randomly assigned to receive either a cage with a …

This early-stage trial tests a new cell-based injection called TG-C for people with long-term lower back pain due to degenerative disc disease. 24 adults aged 22 to 70 will receive either a high, mid, or low dose of TG-C injected into the spinal disc, or a sham (fake) injection. …

This trial is testing whether ProteiOS®, a growth factor derived from donor bone, can help bones in the lower spine fuse together as effectively as the standard approach using a patient's own bone. Adults with degenerative spine conditions needing lumbar fusion surgery will be ra…

This trial tests whether adding a posterior cervical fusion (using the CORUS PCSS 3D device) to the standard anterior cervical discectomy and fusion (ACDF) improves bone fusion success for people with two-level degenerative disc disease in the neck. About 225 adults with neck or …

This study tests a new medicine called CBT005, a healing protein injected directly into damaged spinal discs. The goal is to see if it is safe and can reduce long-term back pain in 60 adults with disc degeneration. Participants get one injection and are followed for up to 3 years…

This study follows 150 people who received a BDyn spine implant for degenerative disc disease to see how many need additional surgery at the level above the implant over at least 4 years. Participants will complete surveys, undergo imaging, and report any side effects. The goal i…

This study looks back at medical records of 300 people who had neck spine fusion surgery using a special graft material called NMP®. The goal is to see how safe it is by checking for complications and whether patients needed another surgery within 90 days to 2 years. The research…

This study looks at whether CT scans taken during lumbar spine surgery can detect spinal instability more reliably than standard X-rays taken before surgery. Researchers will review imaging and medical records from 100 adults undergoing surgery for degenerative spine conditions. …

This study will compare two types of nerve blocks—lumbar paravertebral block and lumbar erector spinae plane block—for pain control after lumbar spine surgery in people aged 65 and older. The goal is to see which block reduces the need for opioid painkillers in the first 48 hours…

This study compares two types of nerve blocks (thoracolumbar interfascial plane block and retrolaminar block) to see which one helps patients recover better after lumbar spine fusion surgery. 70 adults scheduled for surgery will receive one of the two blocks before the procedure.…

This study compares a specialized posture-correction exercise program (Mirror Image Spine Correction) with standard physiotherapy for adults with sciatica. Over 12 weeks, 64 participants will receive supervised sessions three times per week. The main goal is to see if the new exe…

This trial tests whether an extra consultation using a predictive tool, called Dialogue Support, helps adults scheduled for lumbar spine surgery understand their likely outcomes. The tool estimates how a patient may fare one year after surgery and presents that information visual…

This study aims to create a tool that predicts which patients are likely to have persistent pain after lumbar spine surgery, a condition known as failed back surgery syndrome. Researchers will combine routine blood tests, MRI scans, and psychological questionnaires from 150 adult…

This study looks at how different types of obesity—central (belly fat) versus peripheral (fat elsewhere)—affect blood loss and complications during major lower back surgery. Researchers will measure pressure inside the abdomen and blood loss in 90 adults having lumbar spine surge…

This study reviews medical records of 120 adults with low back pain who completed 15 sessions of physical therapy. Researchers will group patients based on their MRI results (disc herniation, disc degeneration, or normal findings) to see if certain types of back pain respond bett…

This study looks at 96 adults with lower back pain to see if the damage shown on an MRI matches how much pain they actually feel. Participants will fill out pain and disability questionnaires and get a physical exam. The goal is to help doctors better understand and treat back pa…

This study will follow 120 adults receiving a steroid injection for lower back and leg pain caused by a slipped disc. Researchers want to see how factors like anxiety, pain during the procedure, and sedation affect how satisfied patients feel one hour after the injection. The goa…