Lobular breast carcinoma in situ
MONDO:0006270A non-invasive adenocarcinoma of the breast characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma.
Also known as: LCIS, lobular Ca in situ of breast, lobular Ca in situ of the breast, lobular breast carcinoma in situ, lobular carcinoma in situ, lobular carcinoma in situ (LCIS), lobular carcinoma in situ of breast, lobular carcinoma in situ of the breast
2840 clinical trials for this condition and its sub-types, 27 tagged with Lobular breast carcinoma in situ itself.
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Can a drug shrink precancerous breast cells before surgery?
Disease control CompletedThis study tested whether a drug called ruxolitinib can reduce abnormal breast cells in people with high-risk or precancerous breast conditions like DCIS or atypical hyperplasia. Half of the 84 participants took ruxolitinib for about 15 days before surgery, and the other half too…
Phase 2 • Sponsor: Julie Nangia • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Can a Hormone-Binding protein predict breast cancer risk? trial tests tamoxifen and fasting
Prevention CompletedResearchers are testing whether low-dose tamoxifen or a 5:2 intermittent fasting diet can raise levels of a protein called sex hormone binding globulin (SHBG) in women at high risk of breast cancer. Higher SHBG levels have been linked to lower breast cancer risk. The trial enroll…
Phase 2 • Sponsor: European Institute of Oncology • Aim: Prevention
Last updated Sep 13, 2026 00:00 UTC
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Baby tamoxifen shows promise in preventing breast cancer recurrence
Prevention CompletedThis study follows up on women who took a low dose of tamoxifen (5 mg daily) for three years to see if it continues to prevent breast cancer over the long term. The original trial found a 42% reduction in breast cancer events. Researchers will also combine data from three similar…
Sponsor: Ente Ospedaliero Ospedali Galliera • Aim: Prevention
Last updated Jun 27, 2026 11:00 UTC
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New study tests skills training to help breast cancer survivors overcome Long-Term pain
Symptom relief CompletedThis study tested two behavioral programs—coping skills training and general health education—to see which better improves well-being in people with ongoing pain after breast cancer surgery. About 316 participants who had surgery for breast cancer or precancerous conditions took …
Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Rare breast lesions under the microscope: study seeks better care
Knowledge-focused CompletedThis study looked back at medical records of over 1,000 people with rare breast conditions called florid and pleomorphic lobular carcinoma in situ (FLCIS and PLCIS). The goal was to understand how doctors currently diagnose and treat these conditions, since there are no official …
Sponsor: Istituto Oncologico Veneto IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC