Legg-Calve-Perthes disease
MONDO:0007885A hip region disease that is characterized by uni- or bilateral avascular necrosis (AVN) of the femoral head in children. In a small percentage of cases, mutations in the COL2A1 gene were found to be responsible.
Also known as: Legg Calvé Perthes Disease, Legg-CALVE-Perthes disease, Legg-Calve-Perthes disease, Legg-Calve-Perthes symptom, Legg-Calve-Perthes syndrome, Legg-Calvé-Perthes disease, Legg-Perthes disease, Osteochondrosis of the capital femoral epiphysis
10 clinical trials for this condition and its sub-types, 9 tagged with Legg-Calve-Perthes disease itself.
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Could your own bone marrow cells save your hip from collapse?
Disease control Recruiting nowThis study tests whether adding a patient's own concentrated bone marrow cells to a standard hip surgery (core decompression) can prevent the hip ball from collapsing and delay or avoid the need for a hip replacement. It includes 192 adults with early-stage osteonecrosis (before …
Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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Bone drug alendronate tested for sickle cell patients
Disease control Recruiting nowThis study tests whether alendronate, a drug used for osteoporosis, can help adults with sickle cell disease who have bone damage (osteonecrosis). Thirty participants will take a weekly pill for 24 weeks. The main goals are to see if the treatment is feasible and safe, and to mea…
Phase 2 • Sponsor: University of California, Davis • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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New knee system aims to improve mobility after failed replacement
Disease control Recruiting nowThis study is testing a new knee replacement system called Persona Revision for people who need a second knee replacement surgery. The goal is to see if it improves knee function, reduces pain, and is safe. About 380 adults will be followed for two years after surgery.
Sponsor: Zimmer Biomet • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Blood test could catch hip disease before It's too late
Diagnosis Recruiting nowThis study is looking for substances in the blood that can help doctors diagnose osteonecrosis of the femoral head (a condition where the hip bone dies) much earlier. Currently, many cases are missed or misdiagnosed. Researchers will collect blood from 300 people with suspected h…
Sponsor: The First Affiliated Hospital of Xinxiang Medical College • Aim: Diagnosis
Last updated Jun 27, 2026 12:23 UTC