Laminopathy
MONDO:0021106A rare genetic disorder caused by mutations in genes encoding proteins of the nuclear lamina.
25 clinical trials for this condition and its sub-types, 3 tagged with Laminopathy itself.
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Sub-types of Laminopathy
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Familial partial lipodystrophy 13 trials · 14 incl. sub-types
10 sub-types
- Familial partial lipodystrophy, Dunnigan type 4 trials
- AKT2-related familial partial lipodystrophy 0 trials
- CIDEC-related familial partial lipodystrophy 0 trials
- LIPE-related familial partial lipodystrophy 0 trials
- PLIN1-related familial partial lipodystrophy 0 trials
- PPARG-related familial partial lipodystrophy 0 trials
- Autosomal semi-dominant severe lipodystrophic laminopathy 0 trials
- Familial partial lipodystrophy, Kobberling type 0 trials
- Lipodystrophy, familial partial, type 8 0 trials
- Lipodystrophy, familial partial, type 9 0 trials
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Hutchinson-Gilford progeria syndrome 3 trials
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Autosomal dominant Emery-Dreifuss muscular dystrophy 0 trials · 3 incl. sub-types
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Greenberg dysplasia 2 trials
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Buschke-Ollendorff syndrome 0 trials
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Pelger-Huet anomaly 0 trials
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3 sub-types
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Atypical Werner syndrome 0 trials
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Restrictive dermopathy 1 0 trials
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New hope for rare fat disorder: experimental drug mibavademab under safety review
Disease control CompletedThis study tests the safety of switching from the current drug metreleptin to a new experimental drug called mibavademab in people with generalized lipodystrophy, a rare condition where the body cannot properly store fat. Nine participants who have been stable on metreleptin will…
Phase 3 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Could a simple breakfast replace the glucose drink for diabetes testing?
Diagnosis CompletedThis trial explores whether a standardized breakfast and a continuous glucose monitor can replace the traditional glucose drink test for diagnosing diabetes and prediabetes in people with Dunnigan's lipodystrophy, a rare genetic condition that causes severe insulin resistance. Th…
Sponsor: Centre Hospitalier Universitaire de la Réunion • Aim: Diagnosis
Last updated Aug 08, 2026 00:03 UTC
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Rare fat disorder may quietly fuel hidden inflammation
Knowledge-focused CompletedResearchers are studying whether adults with Dunnigan lipodystrophy, a rare genetic condition that changes how the body stores fat, have higher levels of inflammation than people without it. The trial enrolls 64 non-diabetic adults on Reunion Island, including those with the cond…
Sponsor: Centre Hospitalier Universitaire de la Réunion • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Researchers investigate Cortisol's role in rare fat disorder
Knowledge-focused CompletedThis study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this dis…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Could a single DNA test solve the mystery of rare brain diseases in kids?
Knowledge-focused CompletedThis study looked at whether whole genome sequencing (a complete read of a person's DNA) can help diagnose leukodystrophies, a group of rare brain diseases that are hard to identify. Researchers enrolled 236 children with white matter abnormalities on brain scans but no known gen…
Sponsor: Children's Hospital of Philadelphia • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC