Keratinization disease

This early-phase trial tests whether low doses of erlotinib, a drug originally used for cancer, can improve symptoms of rare genetic skin conditions called keratinopathies. About 44 adults with confirmed diagnoses will take increasing doses over 24 weeks. The goal is to see if it…

This study tests whether freezing precancerous skin spots (cryotherapy) followed by a medicated ointment (tirbanibulin) works better than freezing alone for actinic keratosis on the scalp and forehead. About 59 adults with at least 8 spots will receive the combo treatment or a pl…

This early-phase trial tests whether adding a dietary supplement called LC-K76 to standard hormone therapy is safe for men with metastatic hormone-sensitive prostate cancer. Forty men will receive the supplement plus hormone therapy for 24 weeks, then be followed for another 24 w…

This study asks whether an artificial intelligence algorithm can accurately diagnose seborrheic keratosis—a common, non-cancerous skin growth—from tissue samples. Researchers will compare the AI's performance against certified dermatopathologists using 30 preserved slides. The go…

This study compares several non-invasive methods to measure foot calluses (plantar hyperkeratosis) in 50 people, half with diabetes and half without. The goal is to find the most reliable technique for assessing callus hardness and stiffness, which could help prevent foot ulcers …

This study looks at whether a test called minimal residual disease (MRD) can help predict how well treatment works in men with metastatic hormone-sensitive prostate cancer. Researchers will track 50 newly diagnosed patients to see how different gene patterns affect treatment resp…