Ischemic disease

This study compares two strategies for placing stents in people with multiple blocked heart arteries. One group gets standard guidance using a pressure wire (FFR), while the other also uses an imaging catheter (OCT) to spot unstable plaques. The goal is to see if the combined app…

This study tests whether a combination of high-dose statins, blood pressure medications (ACE inhibitors or ARBs), and low-dose aspirin can reduce the risk of death, heart attack, stroke, or hospitalization in women who have chest pain or shortness of breath but no major blockages…

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This study tested a stem cell treatment (HB-adMSCs) in one 84-year-old man who had a stroke. The cells were taken from his own fat tissue and given through an IV every 28 days for 6 doses. The goal was to see if it was safe and could help him recover. The study is no longer avail…

This study was designed to test the safety of a gene therapy called VM202 in people with chronic refractory myocardial ischemia—severe chest pain that doesn't improve with standard treatments. The therapy would be injected directly into the heart via a catheter. However, the tria…

This study looks at whether measuring lactate in stool can help doctors predict how well critically ill patients with low blood flow will respond to treatment. About 40 adults in the ICU will provide a stool sample within 24 hours of admission. Researchers will check if high stoo…

This study tests a small sensor placed in reconstructed tissue after flap surgery. The sensor measures CO2 and temperature continuously for up to 10 days to detect early signs of poor blood flow. If it works, doctors could be alerted sooner and take action to save the tissue. Abo…

This study tests a small sensor placed in the muscle of a replanted arm or leg after traumatic amputation. The sensor continuously measures carbon dioxide and temperature to detect blocked blood flow early. If a problem is found, doctors can quickly operate to restore blood flow.…

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study looks at two methods for setting the pressure of a tourniquet (a tight band that stops blood flow) during surgery for a broken wrist. The goal is to see which method gives surgeons a clearer view, causes less pain, and leads to fewer complications. About 140 adults hav…

This study involves 500 people who have chest pain or other signs of heart trouble, but whose main heart arteries are not blocked. Researchers use special tools during a heart catheterization to measure tiny blood vessel function and look for hidden causes like microvascular dise…