Intracranial hypotension
MONDO:0006811Reduction of cerebrospinal fluid pressure characterized clinically by headache which is maximal in an upright posture and occasionally by an abducens nerve palsy (see abducens nerve diseases), neck stiffness, hearing loss (see deafness); nausea; and other symptoms. This condition may be spontaneous or secondary to spinal puncture; neurosurgical procedures; dehydration; uremia; trauma (see also craniocerebral trauma); and other processes. Chronic hypotension may be associated with subdural hematomas (see hematoma, subdural) or hygromas. (From Semin Neurol 1996 Mar;16(1):5-10; Adams et al., Principles of Neurology, 6th ed, pp637-8)
32 clinical trials for this condition and its sub-types, 32 tagged with Intracranial hypotension itself.
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New procedure aims to stop debilitating headaches from spinal fluid leaks
Disease control Recruiting nowThis study tests a procedure called transvenous embolization to treat spontaneous intracranial hypotension, a condition where spinal fluid leaks cause severe headaches. Researchers at Mayo Clinic will enroll 200 people with confirmed CSF-venous fistulas. The goal is to see if blo…
Sponsor: Mayo Clinic • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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New scanner may spot more spinal fluid leaks in mystery headache patients
Diagnosis Recruiting nowThis study compares two types of CT myelography scans to detect CSF-venous fistulas, abnormal connections that cause spinal fluid leaks, in 200 adults with spontaneous intracranial hypotension (low-pressure headaches). Participants will be randomly assigned to receive either a ne…
Sponsor: Duke University • Aim: Diagnosis
Last updated Jun 27, 2026 14:00 UTC
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Inhaled drug combo may ease spinal headache after C-Section
Symptom relief Recruiting nowThis study compares two inhaled treatments—neostigmine/atropine versus lidocaine—for severe headaches that can occur after spinal anesthesia during C-sections. About 111 women aged 18-35 with moderate to severe headache will be randomly assigned to one of the two treatments. The …
Early phase 1 • Sponsor: Minia University • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
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Which drug best stops spinal headaches? new study aims to find out
Symptom relief Recruiting nowThis study compares three medications—theophylline, sumatriptan, and gabapentin—to see which works best for post-dural puncture headache, a severe headache that can occur after a spinal tap or epidural. Researchers will enroll 75 adults aged 21 to 50 who have this type of headach…
Sponsor: Tanta University • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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New drug combo may ease Post-Epidural headaches in new moms
Symptom relief Recruiting nowThis pilot study tests whether two drugs, neostigmine and glycopyrrolate, can treat severe headaches that sometimes occur after an epidural needle accidentally punctures the spinal lining during labor. The study will enroll 18 postpartum women with this type of headache. The goal…
Phase 2 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Less fluid during C-Section may reduce nausea and speed recovery
Symptom relief Recruiting nowThis study tests whether giving less or more IV fluids during a planned C-section helps reduce nausea and vomiting after surgery and helps the bowels recover faster. About 160 women having planned C-sections under spinal anesthesia will take part. The goal is to find the best flu…
Sponsor: Nigde Omer Halisdemir University • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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New nerve block could replace needle in the back for spinal headaches
Symptom relief Recruiting nowThis study tests a nerve block (sphenopalatine ganglion block) against the standard blood patch for treating severe headaches that can happen after a spinal tap or epidural. The nerve block is less invasive and involves numbing the nose. The trial will enroll 80 adults and measur…
Phase 3 • Sponsor: University Hospital, Clermont-Ferrand • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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Nerve block offers hope for debilitating headache sufferers
Symptom relief Recruiting nowThis study looks at whether a nerve block in the back of the head can temporarily relieve severe headaches caused by a spinal fluid leak. About 34 adults with this condition will receive the injection and be monitored for pain changes. The goal is to provide a safe, accessible br…
Sponsor: University Health Network, Toronto • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Eye-Opening clue: ultrasound of the optic nerve may predict spinal headache after C-Section
Knowledge-focused Recruiting nowThis study tests whether measuring the optic nerve sheath diameter with ultrasound can predict post-dural puncture headache (PDPH) in women undergoing elective cesarean delivery under spinal anesthesia. Researchers will also monitor brain oxygen levels to see if drops in oxygen r…
Sponsor: Ordu University • Aim: Knowledge-focused
Last updated Jul 29, 2026 00:00 UTC
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High altitude may raise headache risk after C-Section spinal
Knowledge-focused Recruiting nowThis study will follow 292 women having C-sections with spinal anesthesia to see if those living at high altitudes get more post-dural puncture headaches than those at low altitudes. Researchers will track headache severity and compare groups. The goal is to understand if altitud…
Sponsor: B.P. Koirala Institute of Health Sciences • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:21 UTC