Intermittent vascular claudication

This trial tests whether nicotinamide riboside, a form of vitamin B3, can improve walking ability in people aged 50 and older with peripheral artery disease (PAD). Participants will take either the supplement or a placebo for six months. The main goal is to see if the supplement …

This early-stage trial is testing whether a protein called FGF-1, injected into the leg muscle, is safe and tolerable for people with peripheral arterial disease—a condition where narrowed leg arteries cause pain when walking. The study includes adults aged 50 to 75 with intermit…

This Phase IIa trial tests the safety and tolerability of a new drug called etrinabdione in 30 adults with peripheral arterial disease (PAD). Participants take the drug twice daily for 12 months, starting with a low dose and possibly moving to a higher dose if safe. Researchers w…

This study tests whether a 24-week recreational team handball program can improve walking ability and overall health in 60 men aged 60-80 with peripheral artery disease (PAD) and leg pain when walking. Participants will be randomly assigned to either the handball program or usual…

This study tests a hybrid cardiac rehabilitation program for people with peripheral artery disease (PAD), a condition that reduces blood flow to the legs and causes pain while walking. The program combines in-person supervised exercise sessions with home-based telerehabilitation …

This study looks at whether a CT scan already done for routine care can predict which patients with leg artery disease will improve with supervised exercise therapy. About 40% of patients don't get enough benefit from exercise and need a procedure to open blocked arteries. Resear…

This observational study will examine whether a protein called the GLP-1 receptor is more active in patients with severe leg artery disease compared to those with milder symptoms. Researchers will take one extra blood sample from 50 adults with peripheral artery disease to measur…

This study will test 16 people with peripheral arterial disease (PAD) to see how different types of exercise—walking on a treadmill, traditional strength training, and circuit training—affect blood flow, oxygen levels, and leg pain. Participants will try each exercise type in ran…