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Intellectual disability
MONDO:0001071A broad category of disorders characterized by an impairment to the intelligence an individual possesses. These impairments can result from trauma, birth, or disease and are not restricted to any particular age group.
Also known as: intellectual disabilities, intellectual disability
174 clinical trials for this condition and its sub-types, 137 tagged with Intellectual disability itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Intellectual disability
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Syndromic intellectual disability 2 trials · 38 incl. sub-types
17 sub-types
- Autosomal dominant syndromic intellectual disability 0 trials · 15 incl. sub-types Sub-types →
- X-linked syndromic intellectual disability 0 trials · 12 incl. sub-types Sub-types →
- Smith-Magenis syndrome 5 trials
- Rubinstein-Taybi syndrome 3 trials Sub-types →
- Autosomal recessive syndromic intellectual disability 0 trials · 1 incl. sub-types Sub-types →
- Dyneinopathy 0 trials · 1 incl. sub-types Sub-types →
- 2p25.3 microduplication syndrome 0 trials
- 3q27.3 microdeletion syndrome 0 trials
- 7p22.1 microduplication syndrome 0 trials
- 9p13 microdeletion syndrome 0 trials
- 9q31.1q31.3 microdeletion syndrome 0 trials
- 9q33.3q34.11 microdeletion syndrome 0 trials
- AHDC1-related intellectual disability - obstructive sleep apnea - mild dysmorphism syndrome 0 trials
- CK syndrome 0 trials
- Aplasia cutis-enamel dysplasia syndrome 0 trials
- Intellectual disability, Buenos-Aires type 0 trials
- Intellectual disability, Wolff type 0 trials
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Intellectual disability, autosomal dominant 0 trials · 23 incl. sub-types
29 sub-types
- Autosomal dominant syndromic intellectual disability 0 trials · 15 incl. sub-types Sub-types →
- Autosomal dominant non-syndromic intellectual disability 0 trials · 8 incl. sub-types Sub-types →
- Intellectual disability, autosomal dominant 5 2 trials
- Intellectual developmental disorder, autosomal dominant 64 0 trials
- Intellectual developmental disorder, autosomal dominant 65 0 trials
- Intellectual developmental disorder, autosomal dominant 66 0 trials
- Intellectual developmental disorder, autosomal dominant 67 0 trials
- Intellectual developmental disorder, autosomal dominant 68 0 trials
- Intellectual developmental disorder, autosomal dominant 69 0 trials
- Intellectual developmental disorder, autosomal dominant 70 0 trials
- Intellectual developmental disorder, autosomal dominant 71, with behavioral abnormalities 0 trials
- Intellectual developmental disorder, autosomal dominant 72 0 trials
- Intellectual developmental disorder, autosomal dominant 74 0 trials
- Intellectual developmental disorder, autosomal dominant 75 0 trials
- Intellectual developmental disorder, autosomal dominant 76 0 trials
- Intellectual disability, autosomal dominant 1 0 trials
- Intellectual disability, autosomal dominant 10 0 trials
- Intellectual disability, autosomal dominant 11 0 trials
- Intellectual disability, autosomal dominant 2 0 trials
- Intellectual disability, autosomal dominant 24 0 trials
- Intellectual disability, autosomal dominant 3 0 trials
- Intellectual disability, autosomal dominant 38 0 trials
- Intellectual disability, autosomal dominant 39 0 trials
- Intellectual disability, autosomal dominant 4 0 trials
- Intellectual disability, autosomal dominant 40 0 trials
- Intellectual disability, autosomal dominant 42 0 trials
- Intellectual disability, autosomal dominant 6 0 trials
- Intellectual disability, autosomal dominant 9 0 trials
- Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant 0 trials
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X-linked intellectual disability 1 trial · 15 incl. sub-types
2 sub-types
- X-linked syndromic intellectual disability 0 trials · 12 incl. sub-types Sub-types →
- Non-syndromic X-linked intellectual disability 0 trials · 3 incl. sub-types Sub-types →
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Non-syndromic intellectual disability 0 trials · 10 incl. sub-types
3 sub-types
- Autosomal dominant non-syndromic intellectual disability 0 trials · 8 incl. sub-types Sub-types →
- Non-syndromic X-linked intellectual disability 0 trials · 3 incl. sub-types Sub-types →
- Autosomal recessive non-syndromic intellectual disability 0 trials Sub-types →
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Intellectual disability, autosomal recessive 0 trials · 1 incl. sub-types
3 sub-types
Most studied deeper sub-types
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One-Patient trial aims to treat Ultra-Rare genetic disorder
Disease control Not yet recruitingThis study tests a custom-made drug called an antisense oligonucleotide (ASO) designed for one person with Schuurs-Hoeijmakers syndrome, a rare genetic condition. The drug aims to correct a specific genetic mutation to improve communication and motor skills. Only one participant …
Phase 1/2 • Sponsor: n-Lorem Foundation • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
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Can remote monitoring replace the Dentist's chair for kids with special needs?
Disease control Not yet recruitingThis study will test whether using remote monitoring (like video calls or apps) to manage orthodontic aligner treatment works as well as traditional in-person visits for children aged 11-12 with mild intellectual disability. The main goal is to see if kids stick to their treatmen…
Sponsor: Oasi Research Institute-IRCCS • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Beyond the genome: new Multi-Omics approach aims to crack the code of intellectual disability
Diagnosis Not yet recruitingThis study tests whether combining several advanced genetic analysis techniques can find the cause of intellectual disability or neurodevelopmental disorders in people who have already had standard genetic testing with no answer. Participants will have their existing genetic data…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Diagnosis
Last updated Aug 12, 2026 00:00 UTC
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Saliva test may unlock genetic secrets missed by blood tests
Diagnosis Not yet recruitingThis study tests whether a simple saliva swab can find genetic causes of neurodevelopmental or intellectual disorders when standard blood tests have not. Researchers will use advanced DNA sequencing on cheek cells from 50 participants. The goal is to improve diagnosis and help gu…
Sponsor: Centre Hospitalier Universitaire de Besancon • Aim: Diagnosis
Last updated Jun 27, 2026 12:07 UTC
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Texts and calls could save lives: new study aims to boost baby vaccinations
Prevention Not yet recruitingThis study tests whether sending text messages or voice call reminders with helpful behavior change tips can improve how many babies get their full set of vaccines on time. About 7,800 caregivers of newborns in Bangladesh will be split into three groups: one gets no reminders, on…
Sponsor: Japan Institute for Health Secutiry • Aim: Prevention
Last updated Jun 27, 2026 12:07 UTC
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Could a higher dose of an Alzheimer's drug boost thinking skills in down syndrome?
Symptom relief Not yet recruitingThis early-stage trial will test whether higher-than-standard doses of memantine, a drug already approved for Alzheimer's, are safe and tolerable in 25 adolescents and young adults with Down syndrome. The study also looks for early signs that the drug might improve memory and thi…
Phase 1 • Sponsor: University Hospitals Cleveland Medical Center • Aim: Symptom relief
Last updated Sep 16, 2026 00:00 UTC
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Tiny exercise bursts might sharpen minds in intellectual disability
Symptom relief Not yet recruitingThis study tests whether short, frequent bursts of exercise—called exercise snacks—can improve cognitive function and physical health in adults with mild to moderate intellectual disability. Participants will try three approaches: exercise snacks, a single session of high-intensi…
Sponsor: University of Macau • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
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Thinking through tasks: a new therapy aims to help kids with intellectual disability master daily life
Symptom relief Not yet recruitingThis pilot study tests a therapy protocol based on cognitive-occupational principles (CO-OP) for children and adolescents aged 10-21 with mild to moderate intellectual disability. The intervention involves weekly 45-minute sessions over 12-15 weeks, delivered by occupational ther…
Sponsor: Miri Tal-Saban • Aim: Symptom relief
Last updated Aug 13, 2026 00:00 UTC
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Can acupuncture needles Kick-Start a paralyzed stomach after cancer surgery?
Symptom relief Not yet recruitingThis study tests whether electroacupuncture (mild electrical pulses through thin needles) can help patients whose stomachs stop working properly after surgery for digestive tract tumors. Seventy-six adults who had such surgery and developed gastroparesis (stomach paralysis) will …
Sponsor: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Can School-Based therapy help kids with autism and intellectual disability?
Symptom relief Not yet recruitingThis study will test a new occupational therapy program in schools for children aged 6 to 14 with Autism Spectrum Disorder or Intellectual Disability. The program focuses on improving sensory processing and daily living skills through weekly 50-minute sessions over 10 to 12 weeks…
Sponsor: Çankırı Karatekin University • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Green thumbs, brighter lives: gardening may improve Well-Being in special education students
Symptom relief Not yet recruitingThis study will test whether weekly gardening activities can improve the quality of life for 30 secondary school students with mild intellectual disabilities. For 8 weeks, students will spend about 40 minutes each week planting and caring for plants in a school greenhouse. Resear…
Sponsor: Ordu University • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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VR goggles could ease dental pain for kids with intellectual disability
Symptom relief Not yet recruitingThis study tests whether wearing a virtual reality headset during a dental cleaning can reduce pain in children aged 5 to 7 with mild intellectual disability and moderate dental anxiety. Half of the 102 participants will use VR while the other half receives standard care. Pain le…
Sponsor: Oasi Research Institute-IRCCS • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Virtual reality could take the pain out of teeth cleaning for children with mild intellectual disability
Symptom relief Not yet recruitingThis study tests whether wearing virtual reality goggles during a dental cleaning can reduce how much pain children with mild intellectual disability feel. About 102 children aged 5 to 7 with moderate dental anxiety will take part. Half will use VR during cleaning, and half will …
Sponsor: Oasi Research Institute-IRCCS • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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Can a 6-Week therapy boost Dads' mental health?
Symptom relief Not yet recruitingThis study looks at whether a therapy called Acceptance and Commitment Therapy (ACT) can help fathers of children with special needs feel more flexible in their thinking and improve their mental health. About 50 fathers will take part, with half getting ACT and the other half rec…
Sponsor: The Hong Kong Polytechnic University • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Can a special therapy ease anxiety in kids with autism and intellectual disability? new study aims to find out.
Symptom relief Not yet recruitingThis pilot study will test whether a program called Facing Your Fears can help reduce anxiety in 24 children aged 12-18 who have both autism spectrum disorder and intellectual disability. The program uses cognitive behavioral therapy techniques like gradual exposure to feared sit…
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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New study aims to boost healthcare access for adults with disabilities
Knowledge-focused Not yet recruitingThis study tests whether adding a health education and coaching program to Special Olympics activities helps adults with intellectual or developmental disabilities get better healthcare. About 1,040 athletes and their care partners will take part. The goal is to see if this extra…
Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jul 31, 2026 00:00 UTC
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New study aims to build mental health support for dads of kids with special needs
Knowledge-focused Not yet recruitingThis study aims to create a therapy program using Acceptance and Commitment Therapy (ACT) for fathers of children with special needs in Hong Kong. Researchers will interview 20 fathers and social workers to understand their challenges and what kind of support would help. The goal…
Sponsor: The Hong Kong Polytechnic University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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Rare syndrome study aims to map dental and facial patterns
Knowledge-focused Not yet recruitingThis study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…
Sponsor: University of Milan • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Robot teacher aims to close cancer awareness gap for people with intellectual disabilities
Knowledge-focused Not yet recruitingThis pilot study will test if a friendly robot named Pepper can help 25 adults with intellectual disabilities learn about breast and colorectal cancer. The robot will deliver interactive lessons and quizzes. The goal is to see if this approach boosts cancer knowledge and reduces …
Sponsor: National University of Ireland, Galway, Ireland • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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New study aims to help people with intellectual disability manage emotions better
Knowledge-focused Not yet recruitingThis study looks at how people with mild intellectual disability process emotions compared to those with autism and typically developing individuals. It also tests a special therapy program to help them regulate emotions. 40 people with intellectual disability will take part in t…
Sponsor: Karolinska Institutet • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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New DNA reader could crack unsolved rare disease cases
Knowledge-focused Not yet recruitingThis study tests a new DNA sequencing method that reads long stretches of DNA to find hidden genetic changes causing rare diseases like albinism and intellectual disability. Researchers will analyze stored blood or DNA from 150 patients who haven't gotten a clear diagnosis yet. T…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Can extra decoding lessons boost literacy for nonverbal kids?
Knowledge-focused Not yet recruitingThis study looks at whether adding decoding and encoding practice to the ALLSTAR literacy program helps children with complex communication needs learn to read better. Sixty children aged 5-12 who use augmentative and alternative communication (AAC) will be split into two groups:…
Phase 1/2 • Sponsor: Penn State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC