Inherited kidney disorder
MONDO:0100191A heterogeneous group of genetic conditions, with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology that are characterized by abnormalities in the kidney or urinary system.
Also known as: genetic renal disease, inherited kidney disease, inherited renal disorder, nephrogenetic disorder
317 clinical trials for this condition and its sub-types, 1 tagged with Inherited kidney disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Inherited kidney disorder
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Hereditary nephritis 17 trials · 152 incl. sub-types
7 sub-types
- IgA glomerulonephritis 123 trials
- Alport syndrome 17 trials · 18 incl. sub-types Sub-types →
- Immunoglobulin-mediated membranoproliferative glomerulonephritis 12 trials
- C3 glomerulonephritis 7 trials
- Karyomegalic interstitial nephritis 2 trials
- Balkan nephropathy 1 trial
- Complement factor H deficiency 0 trials Sub-types →
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Familial cystic renal disease 0 trials · 72 incl. sub-types
4 sub-types
- Polycystic kidney disease 13 trials · 65 incl. sub-types Sub-types →
- Autosomal dominant medullary cystic kidney disease with or without hyperuricemia 7 trials Sub-types →
- Adult familial nephronophthisis-spastic quadriparesia syndrome 0 trials
- Autosomal dominant polycystic kidney disease type 1 with tuberous sclerosis 0 trials
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Inherited renal tubular disease 0 trials · 40 incl. sub-types
28 sub-types
- Pseudohypoparathyroidism 8 trials · 9 incl. sub-types Sub-types →
- Cystinuria 7 trials Sub-types →
- Dent disease 5 trials Sub-types →
- Familial primary hypomagnesemia 5 trials Sub-types →
- Nephronophthisis 4 trials Sub-types →
- Oculocerebrorenal syndrome 3 trials
- Jeune syndrome 1 trial · 2 incl. sub-types Sub-types →
- Senior-Loken syndrome 1 trial · 2 incl. sub-types Sub-types →
- Hereditary renal hypouricemia 2 trials Sub-types →
- Nephrogenic diabetes insipidus 1 trial · 2 incl. sub-types Sub-types →
- Pseudohypoaldosteronism type 1 1 trial · 2 incl. sub-types Sub-types →
- EAST syndrome 1 trial
- HELIX syndrome 1 trial
- RHYNS syndrome 1 trial
- Nephrogenic syndrome of inappropriate antidiuresis 1 trial
- Bartter syndrome 0 trials Sub-types →
- Gitelman syndrome 0 trials
- Senior-Boichis syndrome 0 trials Sub-types →
- Autosomal dominant proximal renal tubular acidosis 0 trials
- Autosomal recessive proximal renal tubular acidosis 0 trials
- Cranioectodermal dysplasia 0 trials Sub-types →
- Familial juvenile hyperuricemic nephropathy type 2 0 trials
- Hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome 0 trials
- Inherited Fanconi renotubular syndrome 0 trials Sub-types →
- Mitochondrial DNA depletion syndrome, hepatocerebrorenal form 0 trials
- Nephrogenic diabetes insipidus-intracranial calcification syndrome 0 trials
- Psychomotor regression-oculomotor apraxia-movement disorder-nephropathy syndrome 0 trials
- Renal tubular acidosis, distal, 3, with or without sensorineural hearing loss 0 trials
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Familial nephrotic syndrome 0 trials · 22 incl. sub-types
18 sub-types
- Immunoglobulin-mediated membranoproliferative glomerulonephritis 12 trials
- Idiopathic multidrug-resistant nephrotic syndrome 6 trials
- Nephrotic syndrome 14 3 trials
- Nephrotic syndrome, type 4 1 trial
- LAMB2-related infantile-onset nephrotic syndrome 0 trials Sub-types →
- Congenital nephrotic syndrome, Finnish type 0 trials
- Familial idiopathic steroid-resistant nephrotic syndrome 0 trials Sub-types →
- Nephrotic syndrome 15 0 trials
- Nephrotic syndrome 16 0 trials
- Nephrotic syndrome, IIa 26 0 trials
- Nephrotic syndrome, type 17 0 trials
- Nephrotic syndrome, type 18 0 trials
- Nephrotic syndrome, type 19 0 trials
- Nephrotic syndrome, type 20 0 trials
- Nephrotic syndrome, type 21 0 trials
- Nephrotic syndrome, type 22 0 trials
- Nephrotic syndrome, type 23 0 trials
- Nephrotic syndrome, type 24 0 trials
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Congenital anomaly of kidney and urinary tract 7 trials · 14 incl. sub-types
3 sub-types
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Nephrolithiasis, calcium oxalate 13 trials
2 sub-types
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Neurohypophyseal diabetes insipidus 9 trials
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Hereditary renal cell carcinoma 1 trial · 7 incl. sub-types
7 sub-types
- Hereditary clear cell renal cell carcinoma 4 trials
- PAX6-related ocular dysgenesis 0 trials · 2 incl. sub-types Sub-types →
- Hereditary papillary renal cell carcinoma 2 trials
- Adrenocortical carcinoma, hereditary 0 trials
- Aniridia 2 0 trials
- Aniridia 3 0 trials
- Renal cell carcinoma, Xp11-associated 0 trials
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Inherited focal segmental glomerulosclerosis 1 trial · 4 incl. sub-types
8 sub-types
- HIV-associated nephropathy 2 trials
- Focal segmental glomerulosclerosis 2 1 trial
- Focal segmental glomerulosclerosis 1 0 trials
- Focal segmental glomerulosclerosis 5 0 trials
- Focal segmental glomerulosclerosis 6 0 trials
- Focal segmental glomerulosclerosis 7 0 trials
- Focal segmental glomerulosclerosis 8 0 trials
- Focal segmental glomerulosclerosis 9 0 trials
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Inherited pseudohypoaldosteronism 0 trials · 4 incl. sub-types
2 sub-types
- Pseudohypoaldosteronism type 1 1 trial · 2 incl. sub-types Sub-types →
- Pseudohypoaldosteronism type 2 2 trials Sub-types →
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Renal agenesis 1 trial · 2 incl. sub-types
6 sub-types
- Bilateral renal agenesis 2 trials Sub-types →
- Renal agenesis, unilateral 0 trials
- Renal hypodysplasia/aplasia 1 0 trials
- Renal hypodysplasia/aplasia 2 0 trials
- Renal hypodysplasia/aplasia 3 0 trials
- Renal hypodysplasia/aplasia 4 0 trials
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Liddle syndrome 1 trial
3 sub-types
- Liddle syndrome 1 0 trials
- Liddle syndrome 2 0 trials
- Liddle syndrome 3 0 trials
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Hereditary kidney oncocytoma 1 trial
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Prune belly syndrome 1 trial
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Alsing syndrome 0 trials
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6 sub-types
- Familial juvenile hyperuricemic nephropathy type 1 0 trials
- Familial juvenile hyperuricemic nephropathy type 2 0 trials
- Hyperuricemic nephropathy, familial juvenile type 3 0 trials
- Hyperuricemic nephropathy, familial juvenile type 4 0 trials
- Tubulointerstitial kidney disease, autosomal dominant 6 0 trials
- Tubulointerstitial kidney disease, autosomal dominant, 2 0 trials
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Familial renal glucosuria 0 trials
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Fibronectin glomerulopathy 0 trials
2 sub-types
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2 sub-types
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Nail-patella-like renal disease 0 trials
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1 sub-type
- Renal tubular dysgenesis - ACE 0 trials
Most studied deeper sub-types
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Slower magnesium drip may help sickest patients hold onto the mineral
Disease control Stopped earlyCritically ill patients often have low magnesium, which can lead to heart rhythm problems and other complications. When magnesium is given through an IV, the body keeps only about half of it. Researchers are testing whether giving the same dose over 8 hours instead of 4 hours hel…
Sponsor: CAMC Health System • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Engineered immune cells take aim at Hard-to-Treat cervical cancer
Disease control Stopped earlyThis trial investigates whether specially engineered immune cells (CAR-T cells) can safely treat advanced or recurrent cervical cancer. The cells are designed to recognize and attack cancer cells that carry certain markers like GD2 or Mesothelin. The study involves 20 adults with…
Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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New drug OMS721 tested for rare kidney conditions
Disease control Stopped earlyThis study tested a drug called OMS721 in 31 people with certain kidney diseases, including IgA nephropathy and lupus nephritis. The main goal was to check if the drug is safe and if it reduces protein in the urine, a sign of kidney damage. The study was stopped early, so results…
Phase 2 • Sponsor: Omeros Corporation • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Experimental drug ravulizumab tested for kidney inflammation
Disease control Stopped earlyThis Phase 2 study tested the drug ravulizumab (Ultomiris) in 123 adults with lupus nephritis or IgA nephropathy, two conditions that cause kidney inflammation. Participants received either ravulizumab or a placebo alongside standard care. The study aimed to see if the drug could…
Phase 2 • Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Kidney disease drug trial halted midway
Disease control Stopped earlyThis study tested a drug called OMS721 for people with IgA nephropathy, a kidney disease that can lead to kidney failure. The goal was to see if the drug could reduce protein in the urine, a sign of kidney damage. The trial was stopped early, so results are limited.
Phase 3 • Sponsor: Omeros Corporation • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Kidney disease drug trial halted midway: what happened?
Disease control Stopped earlyThis study tested a drug called ALXN2050 in people with kidney inflammation caused by lupus (lupus nephritis) or IgA nephropathy. The goal was to see if it could reduce protein in the urine, a sign of kidney damage. About 100 adults were planned to take the drug or a placebo alon…
Phase 2 • Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Kidney drug trial halted: venglustat fails to slow disease
Disease control Stopped earlyThis study looked at whether taking venglustat earlier versus later could help people with a fast-progressing form of polycystic kidney disease. The trial was stopped early because the main study found the drug did not work well enough. Only 24 people took part, so no clear concl…
Phase 3 • Sponsor: Sanofi • Aim: Disease control
Last updated Jun 26, 2026 18:08 UTC
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Experimental kidney drug for alport syndrome falls short in early trial
Disease control Stopped earlyThis phase 2 trial tested a weekly injection of lademirsen in 43 adults with Alport syndrome, a genetic condition that damages kidneys. The goal was to see if the drug could slow the decline in kidney function. The study was terminated early, so the results are limited and it's u…
Phase 2 • Sponsor: Genzyme, a Sanofi Company • Aim: Disease control
Last updated Jun 26, 2026 16:08 UTC
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Why are people with this rare bone disorder prone to diabetes?
Knowledge-focused Stopped earlyThis pilot study aims to understand why people with pseudohypoparathyroidism type 1A (PHP1A) have a higher risk of type 2 diabetes. Researchers will measure insulin sensitivity and beta-cell function in 14 participants with PHP1A or related conditions, comparing them to matched h…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC