Familial juvenile hyperuricemic nephropathy type 2

MONDO:0013128

Familial juvenile hyperuricemic nephropathy type 2 is a rare autosomal dominantly inherited disease of childhood characterized by hypoproliferative anemia, hyperuricemia and slowly progressing kidney failure due to dysregulation of the renin-angiotensin system (RAS).

Also known as: ADTKD-REN, FJHN type 2, REN familial juvenile hyperuricemic nephropathy, REN-associated FJHN, REN-associated familial juvenile hyperuricemic nephropathy, REN-associated kidney disease, autosomal dominant tubulointerstitial kidney disease due to mutations in REN, familial juvenile hyperuricemic nephropathy caused by mutation in REN

1 clinical trial for this condition and its sub-types, 0 tagged with Familial juvenile hyperuricemic nephropathy type 2 itself.

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Where it sits in the disease tree

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↑ Inherited renal tubular disease (40) ↑ Familial juvenile hyperuricemic nephropathy (0)

Including sub-types (1) Tagged with Familial juvenile hyperuricemic nephropathy type 2 (0)

Trials to join now! 1

Could a diabetes drug protect kidneys in children with genetic disease?

Disease control Recruiting now

This study tests whether adding dapagliflozin (a diabetes drug) to standard care reduces protein leakage in the urine of children with hereditary kidney diseases. About 44 children will receive either dapagliflozin plus standard care or standard care alone for 12 weeks, then swit…

Phase 3 • Sponsor: Children's Hospital of Fudan University • Aim: Disease control

Last updated Jul 08, 2026 00:00 UTC

Familial juvenile hyperuricemic nephropathy type 2

Where it sits in the disease tree

Could a diabetes drug protect kidneys in children with genetic disease?