Inherited epidermolysis bullosa
MONDO:0019276Inherited epidermolysis bullosa (EB) encompasses a number of disorders characterized by recurrent blister formation as the result of structural fragility within the skin and selected other tissues.
Also known as: epidermolysis bullosa hereditaria, hereditary epidermolysis bullosa
38 clinical trials for this condition and its sub-types, 5 tagged with Inherited epidermolysis bullosa itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Inherited epidermolysis bullosa
-
Epidermolysis bullosa dystrophica 23 trials · 30 incl. sub-types
12 sub-types
- Recessive dystrophic epidermolysis bullosa 21 trials Sub-types →
- Generalized dominant dystrophic epidermolysis bullosa 1 trial
- Acral dystrophic epidermolysis bullosa 0 trials
- Centripetalis recessive dystrophic epidermolysis bullosa 0 trials
- Dystrophic epidermolysis bullosa pruriginosa 0 trials
- Dystrophic epidermolysis bullosa, nails only 0 trials
- Epidermolysis bullosa dystrophica Neurotrophica 0 trials
- Epidermolysis bullosa dystrophica with subcorneal cleavage 0 trials
- Localized dystrophic epidermolysis bullosa 0 trials
- Pretibial dystrophic epidermolysis bullosa 0 trials
- Recessive dystrophic epidermolysis bullosa-generalized other 0 trials
- Transient bullous dermolysis of the newborn 0 trials
-
Junctional epidermolysis bullosa 6 trials · 8 incl. sub-types
15 sub-types
- Junctional epidermolysis bullosa, non-Herlitz type 2 trials Sub-types →
- Epidermolysis bullosa, junctional 2A, intermediate 0 trials
- Epidermolysis bullosa, junctional 2B, severe 0 trials
- Epidermolysis bullosa, junctional 3A, intermediate 0 trials
- Epidermolysis bullosa, junctional 3B, severe 0 trials
- Epidermolysis bullosa, junctional 4, intermediate 0 trials
- Epidermolysis bullosa, junctional 5A, intermediate 0 trials
- Epidermolysis bullosa, junctional 6, with pyloric atresia 0 trials
- Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome 0 trials
- Junctional epidermolysis bullosa Herlitz type 0 trials
- Junctional epidermolysis bullosa inversa 0 trials
- Junctional epidermolysis bullosa with pyloric atresia 0 trials
- Laryngo-onycho-cutaneous syndrome 0 trials
- Late-onset junctional epidermolysis bullosa 0 trials
- Late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome 0 trials
-
Epidermolysis bullosa simplex 6 trials
20 sub-types
- Epidermolysis bullosa simplex 1B, generalized intermediate 1 trial
- Epidermolysis bullosa simplex 1C, localized 1 trial
- Epidermolysis bullosa simplex 1A, generalized severe 0 trials
- Epidermolysis bullosa simplex 1D, generalized, intermediate or severe, autosomal recessive 0 trials
- Epidermolysis bullosa simplex 2A, generalized severe 0 trials
- Epidermolysis bullosa simplex 2B, generalized intermediate 0 trials
- Epidermolysis bullosa simplex 2C, localized 0 trials
- Epidermolysis bullosa simplex 2E, with migratory circinate erythema 0 trials
- Epidermolysis bullosa simplex 2F, with mottled pigmentation 0 trials
- Epidermolysis bullosa simplex 2d, generalized, intermediate or severe, autosomal recessive 0 trials
- Epidermolysis bullosa simplex 3, localized or generalized intermediate, with BP230 deficiency 0 trials
- Epidermolysis bullosa simplex 4, localized or generalized intermediate, autosomal recessive 0 trials
- Epidermolysis bullosa simplex 5A, Ogna type 0 trials
- Epidermolysis bullosa simplex 5B, with muscular dystrophy 0 trials
- Epidermolysis bullosa simplex 5C, with pyloric atresia 0 trials
- Epidermolysis bullosa simplex 6, generalized, with scarring and hair loss 0 trials
- Epidermolysis bullosa simplex 7, with nephropathy and deafness 0 trials
- Epidermolysis bullosa simplex with anodontia/hypodontia 0 trials
- Epidermolysis bullosa simplex with nail dystrophy 0 trials
- Suprabasal epidermolysis bullosa simplex 0 trials Sub-types →
-
Kindler syndrome 0 trials
1 sub-type
Most studied deeper sub-types
-
Experimental drug rigosertib tested against aggressive skin cancer in rare disease patients
Disease control CompletedThis small early-phase trial tested an experimental drug called rigosertib in just 2 people with a rare blistering skin disease (recessive dystrophic epidermolysis bullosa) who also had advanced skin cancer. The goal was to see if the drug could shrink tumors and whether it was s…
Phase 1/2 • Sponsor: Prof. Johann Bauer • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
-
Could botox stop blisters on the soles of people with a rare skin condition?
Symptom relief CompletedResearchers are testing whether injections of botulinum toxin into the soles of the feet can reduce blistering in people with localized epidermolysis bullosa simplex, a rare skin condition that causes painful foot blisters. The trial enrolls 18 people with similar blisters on bot…
Phase 2/3 • Sponsor: University Hospital, Toulouse • Aim: Symptom relief
Last updated Sep 21, 2026 16:00 UTC
-
CBD oil may soothe itch in kids with rare skin disease
Symptom relief CompletedThis study tested whether cannabidiol (CBD) can reduce severe itching in 10 children with a rare genetic skin condition called epidermolysis bullosa. The children took CBD syrup three times a day for a month. Researchers measured itch, pain, sleep, and quality of life before and …
Phase 2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
-
New hope for painful bandage changes in rare skin disease
Symptom relief CompletedThis study tested whether a numbing cream (ropivacaine) can reduce severe pain during bath and dressing changes in children and young adults with epidermolysis bullosa, a rare genetic skin condition. Ten participants applied the cream before dressing changes and reported their pa…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
-
Portable skin dressing shows promise for rare blistering disease
Symptom relief CompletedThis pilot study tested a portable device called Spincare that sprays a nanofiber dressing onto wounds in people with recessive dystrophic epidermolysis bullosa (RDEB), a rare genetic condition causing fragile, blistering skin. Six participants with at least six chronic or recurr…
Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 26, 2026 17:09 UTC
-
Can training ease the burden of caring for fragile skin? new study investigates.
Knowledge-focused CompletedThis study looked at whether specialized training for nurses on how to care for children with a rare, severe skin condition called epidermolysis bullosa (EB) can reduce their stress and anxiety. The study involved 19 nurses and nursing assistants at a hospital in France. Research…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
-
Rare skin disease study uncovers reasons kids avoid painkillers
Knowledge-focused CompletedThis study looked at why children with hereditary epidermolysis bullosa (a rare condition causing fragile skin and painful blisters) often do not take prescribed opioid painkillers before baths and bandage changes. Researchers interviewed 10 children and their parents to understa…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
-
Scientists investigate why skin fails to heal in rare blistering disease
Knowledge-focused CompletedThis study looked at how skin cells from 30 people with recessive dystrophic epidermolysis bullosa (RDEB) grow and repair wounds. RDEB is a rare genetic condition that causes fragile skin and painful blisters. Researchers took small skin samples to study the cells in a lab, aimin…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
-
Braces removal just got safer: new study tests gentle Clean-Up methods
Knowledge-focused CompletedThis study tested two different ways to remove leftover glue from teeth after braces are taken off. 142 people who had braces or clear aligners were split into two groups: one used a special ultrasonic tool, the other used a polishing bur. Researchers checked plaque, bleeding, le…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC