Inflammatory breast carcinoma

This early-phase trial is testing a new combination of three drugs—cyclophosphamide, axatilimab, and retifanlimab—in people with metastatic triple negative breast cancer that has stopped responding to standard treatments. The main goal is to find the safest dose of the new combin…

This phase II trial is testing whether combining two drugs—trastuzumab deruxtecan (Enhertu) and durvalumab—given before surgery can eliminate cancer in people with stage III inflammatory breast cancer that has HER2 protein. The study will enroll 63 participants and measure how ma…

This study tests whether a procedure called lymphovenous bypass, done before underarm lymph node removal, can prevent lymphedema (arm swelling) in patients with breast cancer or melanoma. About 252 participants will receive the bypass during their cancer surgery. Researchers will…

This study tests whether a virtual exercise and education program can help breast cancer patients maintain their fitness, heart health, and quality of life while undergoing chemotherapy. About 120 patients with stage I-III breast cancer will be enrolled. Participants will attend …

This study is a registry that collects information from 200 people with stage III or IV inflammatory breast cancer (IBC). Participants fill out a quality-of-life questionnaire and provide blood samples for MRD testing. The goal is to gather data on how MRD test results relate to …

This study creates a registry for people with inflammatory breast cancer, a rare and aggressive form of the disease. Researchers will collect blood, tissue, and stool samples along with medical information from up to 1,200 participants. The goal is to build a resource for future …

This study is for people with high-risk early breast cancer, including inflammatory breast cancer. Researchers want to see if clusters of tumor cells found in the blood can help predict how well treatment works and the chances of survival. About 130 participants will give blood s…

This study looks at whether a less invasive procedure called sentinel lymph node biopsy can be safely used after chemotherapy in people with inflammatory breast cancer. Traditionally, these patients need more extensive surgery because the cancer is advanced. The study will check …

This study looks at whether special imaging and dye can help doctors find the first lymph nodes that cancer might spread to in people with inflammatory breast cancer. About 50 women with this rare and aggressive cancer will take part. The goal is to see if these methods work well…