Infiltrating bladder urothelial carcinoma

Researchers test whether four cycles of dose-dense MVAC chemotherapy, given with G-CSF support, can shrink or eliminate muscle-invasive bladder cancer before radical surgery. The trial enrolls 24 adults with locally advanced urothelial carcinoma of the bladder who are fit for cis…

This study tested several immunotherapy-based drug combinations in 272 people with advanced bladder cancer that had worsened after platinum chemotherapy. The goal was to see which combinations were safest and most effective at shrinking tumors or slowing the disease. Participants…

This small study tested whether giving the drug sacituzumab govitecan before surgery could help people with a rare type of muscle-invasive bladder cancer. The drug targets cancer cells and delivers chemotherapy directly to them. Only 4 people took part before the study was stoppe…

This study tested a new type of radiation therapy that adapts daily to the patient's anatomy, combined with chemotherapy, for muscle-invasive bladder cancer. The goal was to see if this approach could lower severe bowel and bladder side effects compared to standard radiation. How…

This early study tested adding a testosterone-lowering drug (degarelix) to standard chemotherapy for people with muscle-invasive bladder cancer that has testosterone receptors. Only 2 people enrolled before the study was stopped. The goal was to see if the combination could elimi…

This study tested an experimental drug called enfortumab vedotin, alone or with other cancer drugs, in people with advanced bladder or urinary tract cancer. The goal was to see if the drug could shrink tumors and control the disease. The trial included 348 participants but was te…

This phase 2 study tested several drug combinations (retifanlimab, epacadostat, INCAGN02385, INCAGN02390) given before bladder removal surgery in 30 patients with muscle-invasive bladder cancer who could not take the standard chemo drug cisplatin. The trial was terminated early, …

This study tested whether adding the immunotherapy drug avelumab to standard radiation could help treat muscle-invasive bladder cancer in patients who cannot receive the usual chemotherapy. Fourteen participants received the combination therapy. The goal was to see if the cancer …

This trial tested whether adding gemcitabine to standard cisplatin and radiation therapy could help control muscle-invasive bladder cancer while preserving the bladder. About 69 patients were enrolled to compare the combination against standard treatment. The study was terminated…

This study looked at whether genetic changes found in urine could match those in tumor tissue for people with high-risk non-muscle invasive bladder cancer. The goal was to see if a urine test could help doctors choose the best immunotherapy for each patient. The study planned to …