Immunodeficiency disease
MONDO:0021094Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
Also known as: immuno-deficiency, immunodeficiency, immunodeficiency disorder, immunodeficiency syndrome
776 clinical trials for this condition and its sub-types, 55 tagged with Immunodeficiency disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Immunodeficiency disease
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T-cell immunodeficiency 4 trials · 484 incl. sub-types
3 sub-types
- AIDS 463 trials
- Congenital T-cell immunodeficiency 0 trials · 13 incl. sub-types Sub-types →
- Idiopathic CD4-positive T-lymphocytopenia 6 trials
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B cell deficiency 5 trials · 85 incl. sub-types
5 sub-types
- Agammaglobulinemia 16 trials · 52 incl. sub-types Sub-types →
- Hyperimmunoglobulin syndrome 0 trials · 33 incl. sub-types Sub-types →
- Selective immunoglobulin deficiency disease 1 trial · 4 incl. sub-types Sub-types →
- PAX5-related B lymphopenia and autism spectrum disorder 0 trials
- Immunoglobulin beta deficiency 0 trials
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Combined immunodeficiency 3 trials · 57 incl. sub-types
33 sub-types
- Severe combined immunodeficiency 24 trials · 37 incl. sub-types Sub-types →
- Ataxia telangiectasia 11 trials Sub-types →
- Wiskott-Aldrich syndrome 10 trials
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia 2 trials
- Combined immunodeficiency due to CRAC channel dysfunction 1 trial Sub-types →
- Combined immunodeficiency due to ZAP70 deficiency 1 trial
- Non-SCID combined immunodeficiency 0 trials · 1 incl. sub-types Sub-types →
- IRF4-related combined immunodeficiency 0 trials
- MHC class I deficiency 0 trials Sub-types →
- NFATC1-related combined immunodeficiency 0 trials
- POLD3-related combined immunodeficiency 0 trials
- RAC2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome 0 trials Sub-types →
- Autosomal dominant combined immunodeficiency due to ERBIN deficiency 0 trials
- Autosomal dominant combined immunodeficiency due to partial IL6ST deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to IL6R deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to complete IL6ST deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to partial IL6ST deficiency 0 trials
- Combined immunodeficiency due to CD3gamma deficiency 0 trials
- Combined immunodeficiency due to CTPS1 deficiency 0 trials
- Combined immunodeficiency due to GINS1 deficiency 0 trials
- Combined immunodeficiency due to MALT1 deficiency 0 trials
- Combined immunodeficiency due to OX40 deficiency 0 trials
- Combined immunodeficiency due to POLE2 deficiency 0 trials
- Combined immunodeficiency due to RELA haploinsufficiency 0 trials
- Combined immunodeficiency due to STK4 deficiency 0 trials
- Combined immunodeficiency due to TBX1 deficiency 0 trials
- Combined immunodeficiency due to dimerization defective IKAROS mutation 0 trials
- Combined immunodeficiency due to moesin deficiency 0 trials
- Combined immunodeficiency syndrome 0 trials Sub-types →
- Combined immunodeficiency with low Ig due to BCL10 deficiency 0 trials
- Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to IKBKA deficiency 0 trials
- Early-onset combined immunodeficiency with low ig due to dominant negative IKAROS mutation 0 trials
- Late-onset combined immunodeficiency due to ICOSL deficiency 0 trials
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Complement deficiency 2 trials · 28 incl. sub-types
8 sub-types
- Atypical hemolytic-uremic syndrome 19 trials Sub-types →
- Classic complement early component deficiency 0 trials · 7 incl. sub-types Sub-types →
- Disorder of lectin complement activation pathway 0 trials · 1 incl. sub-types Sub-types →
- Complement factor I deficiency 0 trials
- Complement receptor deficiency 0 trials
- Immunodeficiency due to a classical component pathway complement deficiency 0 trials Sub-types →
- Immunodeficiency due to a late component of complement deficiency 0 trials Sub-types →
- Recurrent Neisseria infections due to factor D deficiency 0 trials
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X-linked lymphoproliferative syndrome 7 trials · 11 incl. sub-types
2 sub-types
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GATA2 deficiency with susceptibility to MDS/AML 5 trials · 8 incl. sub-types
2 sub-types
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Idiopathic CD4 lymphocytopenia 7 trials
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IKBKG-related immunodeficiency with or without ectodermal dysplasia 0 trials · 4 incl. sub-types
3 sub-types
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IRF4-related immune disorder 1 trial
2 sub-types
- IRF4-related combined immunodeficiency 0 trials
- Immunodeficiency 131 0 trials
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Immunodeficiency 23 1 trial
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Immunodeficiency 31B 1 trial
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DOCK2 deficiency 0 trials
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FADD-related immunodeficiency 0 trials
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FASLG-related immunodeficiency 0 trials
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FNIP1-associated syndrome 0 trials
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Shwachman-Diamond syndrome 1 0 trials
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TNFRSF9-related immunodeficiency 0 trials
1 sub-type
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Wiskott-Aldrich syndrome 2 0 trials
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Hatipoglu immunodeficiency syndrome 0 trials
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Hypoproteinemia, hypercatabolic 0 trials
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Immunodeficiency 102 0 trials
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Immunodeficiency 112 0 trials
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Immunodeficiency 117 0 trials
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Immunodeficiency 118 0 trials
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Immunodeficiency 119 0 trials
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Immunodeficiency 122 0 trials
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Immunodeficiency 125 0 trials
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Immunodeficiency 127 0 trials
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Immunodeficiency 128 0 trials
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Immunodeficiency 132b 0 trials
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Immunodeficiency 15a 0 trials
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Immunodeficiency 35 0 trials
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Immunodeficiency 45 0 trials
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Immunodeficiency 53 0 trials
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Immunodeficiency 57 0 trials
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Immunodeficiency 60 0 trials
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Immunodeficiency 62 0 trials
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Immunodeficiency 64 0 trials
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Immunodeficiency 66 0 trials
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Immunodeficiency 67 0 trials
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Immunodeficiency 69 0 trials
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Immunodeficiency 70 0 trials
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Immunodeficiency 75 0 trials
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Immunodeficiency 76 0 trials
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Immunodeficiency 77 0 trials
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Immunodeficiency 81 0 trials
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Immunodeficiency 84 0 trials
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Immunodeficiency 85 and autoimmunity 0 trials
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Immunodeficiency 86 0 trials
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Immunodeficiency 87 and autoimmunity 0 trials
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Immunodeficiency 88 0 trials
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Immunodeficiency 89 and autoimmunity 0 trials
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Immunodeficiency 92 0 trials
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Immunodeficiency 95 0 trials
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Immunodeficiency 96 0 trials
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Lymphoproliferative syndrome 1 0 trials
Most studied deeper sub-types
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Rewriting the code: a One-Time gene fix for a rare immune disease?
Cure By invitation onlyThis trial tests a one-time gene therapy for WHIM syndrome, a rare inherited immune disorder that causes severe infections. Doctors collect a person's own blood stem cells, use base editing to correct the faulty CXCR4 gene, and return the edited cells to the body. The goal is to …
Phase 1/2 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Cure
Last updated Sep 20, 2026 00:00 UTC
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New drug could make stem cell transplants safer for rare immune disorder
Disease control OngoingThis phase II trial tests whether a new drug called Briquilimab can make stem cell transplants safer for people with GATA2 deficiency, a rare genetic condition that weakens the immune system and raises the risk of infections and blood cancers. The study involves 13 participants a…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 13, 2026 00:00 UTC
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Gene therapy for 'Bubble Boy' disease under Long-Term watch
Disease control By invitation onlyThis study follows about 50 people with a rare immune disorder called ADA-SCID who have received a gene therapy treatment called Strimvelis. The goal is to track their health for many years to see if the treatment remains safe and effective. Researchers will monitor for side effe…
Sponsor: Fondazione Telethon • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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Quick-Push immune therapy studied for safety and ease
Disease control OngoingThis study looks at whether giving Cutaquig® (a medicine that helps fight infections) by a faster manual push method is safe and easy for adults with primary or secondary immunodeficiency. About 36 participants will use the rapid push method at home. The goal is to see if this ap…
Sponsor: University of Alberta • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Promising pneumonia therapy trial pulled before it began
Disease control CancelledThis study was designed to test whether adding an experimental drug and special immune cells to standard care could help critically ill adults with severe pneumonia, especially those with sepsis or lung failure. The trial was withdrawn before enrolling any participants, so no res…
Phase 3 • Sponsor: ImmunityBio, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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New stem cell approach could fix immune systems in kids
Disease control OngoingThis Phase II trial tests a stem cell transplant from unrelated or partially matched family donors for children and young adults with severe immune deficiencies. The stem cells are specially processed to remove certain immune cells, aiming to reduce complications. The goal is to …
Phase 2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Opioid use may weaken flu shots in HIV patients, study suggests
Knowledge-focused OngoingThis study looks at how opioid use affects the immune system's response to the flu vaccine in people with and without HIV. Researchers will analyze blood samples from 400 participants to measure antibody levels and immune cell activity. The goal is to understand why opioid users …
Phase 4 • Sponsor: University of Miami • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Holistic education study for stress withdrawn before starting
Knowledge-focused CancelledThis study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …
Sponsor: Goddess Zena I. Jones • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC