Hypogonadism

Researchers are testing an oral form of native testosterone called DITEST in men with primary or secondary hypogonadism. The trial measures how much testosterone reaches the blood after a single dose, both with and without food, and compares it to an existing oral testosterone tr…

This study tested a natural product called FPT-20 in 16 men with sperm production problems due to testicular inflammation. Participants took one tablet daily for 6 to 12 months. The goal was to see if the supplement could increase sperm count and improve semen quality.

This study looked at whether testosterone therapy can improve bone health in men who have both type 2 diabetes and low testosterone. About 92 male veterans aged 35 to 70 took part. Researchers measured bone strength using special scans and blood tests over 12 months to see if tes…

This early study tested whether a naturally occurring hormone called kisspeptin can stimulate reproductive hormones and help women with hypothalamic amenorrhea (a condition where periods stop due to low hormone levels) release eggs. Thirteen women received pulsatile injections of…

This study looked at whether testosterone replacement therapy can improve dry eye symptoms in men with low testosterone. Researchers measured tear quality and eye surface health in 77 men before and during treatment. The goal was to see if hormone therapy could help manage dry ey…

This study tested whether giving testosterone to older women with chronic back pain and low testosterone could improve pain, physical function, and quality of life. 36 women received weekly injections of either testosterone or a placebo for several weeks. The goal was to see if t…

This study looked at people with low or no GnRH, a hormone that controls puberty and fertility. Researchers studied 111 adults and teens to understand how GnRH problems affect the body. The goal was to find new hormone patterns and genetic causes, not to test a treatment.

This completed Phase 2 trial tested a natural hormone called kisspeptin in 18 adults with hypogonadotropic hypogonadism, a condition where the body doesn't produce enough sex hormones. Participants received different doses of kisspeptin to see how it affected hormone pulses. The …

This study aims to find the genes involved in inherited reproductive disorders, such as delayed or early puberty and low hormone levels. Researchers will analyze genetic data from 600 participants with these conditions. The goal is to identify genetic variations that may explain …

This study looked at how a drug that blocks opioids (naloxone) affects hormone signals in the brain related to testosterone. 23 men with a condition called hypogonadotropic hypogonadism (low testosterone) took part. The goal was to understand the body's hormone control, not to tr…

This study looked at whether giving older men testosterone for a few weeks, with or without resistance exercise, could create a lasting 'muscle memory' that makes it easier to regain muscle later. Forty-five sedentary men aged 55-70 received either testosterone or placebo injecti…

This study tested whether a new liquid form of follitropin alfa (a hormone used for fertility) works the same as the standard powder form. Fifty-five healthy men with low testosterone levels were given both versions at different times. The goal was to compare how the drug is abso…