Hypersensitivity reaction disease

This study tests a new dissolving film called DESF that delivers epinephrine under the tongue. It is designed for children ages 7 to 17 who weigh at least 30 kg and have a history of allergic reactions that put them at high risk for severe episodes like anaphylaxis. The goal is t…

This study tested whether adding the drugs omalizumab (Xolair) or dupilumab (Dupixent) to oral immunotherapy (OIT) helps people with multiple food allergies tolerate more allergens. 130 participants aged 4 to 55 with allergies to peanut plus one or two other foods were enrolled. …

This study tested the drug dupilumab (Dupixent) in 10 people with a chronic skin condition called dermal hypersensitivity reaction. Participants received injections of dupilumab every two weeks for 24 weeks. Researchers looked at changes in immune cells in the skin and how much b…

This Phase 2 study tested a new dissolvable film called DESF that delivers epinephrine under the tongue. Thirty-six healthy adults with oral allergy syndrome received DESF and standard epinephrine injections to compare how quickly the drug enters the bloodstream. The goal is to s…

Researchers at Lund University Hospital are testing a new MRI technique called DIVIDE to see if it can measure how sensitive brain metastases are to radiation. Today, doctors only see whether radiation worked by watching tumor size change on scans weeks or months later. This tria…

This study tested whether giving full therapeutic doses of anaesthetics like propofol and ketamine can safely diagnose drug allergies in people who had a suspected allergic reaction during surgery. Fifty adult patients with a history of perioperative hypersensitivity underwent in…

This study looked at ways to reduce breathing problems and allergies in over 1,100 Norwegian salmon industry workers. The goal was to find practical changes in the workplace that lower workers' exposure to dust and other particles that can cause asthma. Researchers measured air q…

This study tested whether a topical serum containing Mitopure causes skin irritation or allergic reactions. 112 healthy adults, half with sensitive skin, wore patches with the serum repeatedly. The goal was to see if the product is safe for skin use.

This study tested three ways of giving the steroid dexamethasone to prevent allergic reactions from the chemotherapy drug paclitaxel in 90 women with breast or gynecologic cancer. One group took oral dexamethasone the night before and morning of treatment, another got it intraven…

This study tested whether a toothpaste containing 8% arginine can reduce tooth sensitivity better than a regular cavity-protection toothpaste. Eighty adults with sensitive teeth used one of the two toothpastes for eight weeks. The main goal was to measure how much their sensitivi…

This study looks at whether people who have had a Prineo dressing before are more likely to develop an allergic skin reaction when it is used again after joint replacement surgery. Researchers will compare first-time users with those who have had the dressing in the past, trackin…

This study tested whether children under 16 with a history of mild beta-lactam (like penicillin) allergies could safely take the drug again without first having skin tests. Researchers used a questionnaire to identify low-risk kids and then gave them an oral dose. The goal was to…

This study tested whether 6 different skin patches containing Mitopure cause irritation or allergic reactions. A total of 113 healthy adults, half with sensitive skin, wore the patches repeatedly. The goal was to check skin safety, not to treat any disease.

This study aimed to find the right strength of two grass allergen extracts (timothy and orchard grass) to cause a skin reaction similar to histamine. Thirty-one adults with grass pollen allergies received skin prick tests with different concentrations. The goal was to improve all…

This study looks at 55 adults with diabetes who are either allergic to insulin or not, to better understand and diagnose insulin allergy. Researchers will test a step-by-step diagnostic approach and study the immune system's role. The goal is to make it easier to identify the exa…