Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Full-Dose drug testing could pinpoint surgery allergies

NCT ID NCT06065137

Diagnosis Sponsor: University Hospital, Antwerp Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether giving full therapeutic doses of anaesthetics like propofol and ketamine can safely diagnose drug allergies in people who had a suspected allergic reaction during surgery. Fifty adult patients with a history of perioperative hypersensitivity underwent incremental drug provocation testing. The goal was to see how often allergic reactions occur during this direct testing and to compare it with standard skin tests.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propofol and ketamine
What this could lead to
If successful, this could provide a safer, more accurate way to diagnose which anaesthetic drugs cause allergic reactions during surgery.
What could go wrong
This is a small, completed study with only 50 participants, so results may not apply to everyone. Drug provocation testing itself carries a risk of triggering an allergic reaction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Oct 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients consulting the allergology department of the Antwerp University hospital medical with a history consistent with perioperative hypersensitivity * Indication for diagnostic work-up as determined at an interdisciplinary meeting between allergologists and anaesthetists * willing to sign separate informed consent forms for both general anaesthesia and the Drug Provocation Test. Exclusion Criteria: * patient refusal * incomplete diagnostic work-up * history inconsistent with perioperative hypersensitivity

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Allergic reaction are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

allergic disease anaphylaxis drug allergy hypersensitivity reaction disease Hypersensitivity, Immediate IgE responsiveness, atopic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Allergic reaction Anaphylactic reaction Anaphylaxis Hypersensitivity Hypersensitivity, drug Immediate hypersensitivity Perioperative complication

Contacts and locations

Locations

  • Antwerp University Hospital

    Edegem, Antwerp, 2650, Belgium

More trials for these conditions

Other studies related to the condition(s) this trial covers.