Shorter steroid regimen may prevent chemo allergies just as well

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult female patients \> 18 years of age 2. Patients of the Loma Linda University Health (LLUH) gynecologic oncology and breast oncology service 3. Confirmed breast or gynecologic cancer diagnosis of any stage and any gynecologic or breast malignancy 4. Planned treatment with paclitaxel containing regimen either in the adjuvant setting or for palliation 5. Planned treatment with paclitaxel should be for 3 or more cycles given as a weekly or every 3 weeks cycle 6. Paclitaxel should be given as a monotherapy or as part of a combination regimen. If paclitaxel is part of a regimen containing other drugs, the following conditions must be met: 1. Paclitaxel will be the first chemotherapy regimen to be infused when patient comes in for treatment 2. Chemotherapy regimen that would be approved for the study are the following: i. Paclitaxel/ Carboplatin ii. Paclitaxel/Carboplatin/Bevacizumab iii. Paclitaxel/Cisplatin/Bevacizumab iv. Paclitaxel/Bevacizumab v. Paclitaxel/ Ifosfamide vi. Paclitaxel/ Pazopanib 7. Patients should have no prior exposure to taxanes (this includes: paclitaxel, docetaxel, and protein-bound paclitaxel) 8. The chemotherapy treatment should be at one of the LLUH Adult Cancer Centers 9. The patient should be an English or Spanish speaking patient Exclusion Criteria: 1. Patients who are not with the gynecologic or breast oncology service 2. Patients who are with the gynecologic oncology or breast oncology service but are not receiving paclitaxel either as a monotherapy or in combination with other regimen 3. Patients who have had prior exposure to taxanes (this includes: paclitaxel, docetaxel, and protein-bound paclitaxel) 4. Patients who are currently on steroid therapy and it is anticipated that therapy will not be discontinued at least a week prior to start of chemotherapy 5. Patients with autoimmune diseases, malignancies, and any other co-morbid condition that might require steroid therapy during chemotherapy. This includes, but not limited to: 1. Crohn's disease 2. Immune thrombocytopenia 3. Lupus nephritis 4. Multiple sclerosis 5. Primary brain tumors 6. Multiple Myeloma 7. Hodgkin's Lymphoma 6. Patients with uncontrolled diabetes or diabetic or pre-diabetic patients with baseline A1C levels \> 8.5 7. Patients who are allergic to diphenhydramine and/or dexamethasone 8. Non-English and Non-Spanish speaking patients